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48186-01 - Lecture: Laser and Optics in Medicine 6 CP

Semester spring semester 2020
Course frequency Every spring sem.
Lecturers Ferda Canbaz (
Azhar Zam (, Assessor)
Content Introduction:
Nature of light, fundamentals of light-matter interactions, photobiology, photophysics, photochemistry, laser and light sources, laser safety.

Light-Tissue Interactions:
Photochemical interaction, biostimulation, photo-thermal effects, photoablation, plasma-induced ablation, photo-acoustic effects, photon transport, monte carlo simulations, adding doubling method.

Absorption, diffuse reflectance, fluorescence, Raman and tissue spectroscopy

Principles of optical biosensing, optical geometries for biosensors and biosensing methods.

Bioimaging Principles and Techniques:
Introduction to optical microscopy, principle of image formation, amplitude and phase microscopy, polarization, fluorescence and confocal microscopy, optical diffraction tomography and new microscopic techniques.

2D Bioimaging:
Endoscopy, videomicroscopy, diffuse reflectance, laser Doppler perfusion imaging, laser speckle perfusion imaging, .

3D Bioimaging:
Optical coherence tomography, polarimetry, diffuse optical tomography, photothermal imaging, photoacoustic imaging and optical biopsy.

Applications Laser and Optics in Medicine and Biology:
Biophotonics applications in medicine, laser tweezers and scissors, microarray and microfluidic technologies for genomics and proteomics, flow cytometry, bioluminescence, bio-nanophotonics, opto-genetics, tissue engineering with light and data analysis in Biophotonics.
Bibliography Recommended Reading:
Prasad, P.N., “Introduction to Biophotonics”, (Wiley-VCH), 2003
Wang, LV and Wu HI, Biomedical Optics, Principles and Imaging, (Wiley-VCH), 2007,
Demchenko, A P "Introduction to Fluorescence Sensing", Springer, 2008
Popp,Tuchin, Chiou, Heinemann (Editors) Handbook of Biophotonics, 3 Volume Set, (Wiley-VCH), 2012.
Leahy, M.J. editor, Microcirculation Imaging, (Wiley-VCH), 2012.
Weblink DBE


Language of instruction English
Use of digital media No specific media used


Interval weekly
Date 19.02.2020 – 27.05.2020
Time Wednesday, 09.00-11.45 Gewerbestrasse 14, Vorlesungsraum DBE 14.03.002
Date Time Room
Wednesday 19.02.2020 09.00-11.45 Gewerbestrasse 14, Vorlesungsraum DBE 14.03.002
Wednesday 26.02.2020 09.00-11.45 Gewerbestrasse 14, Vorlesungsraum DBE 14.03.002
Wednesday 04.03.2020 09.00-11.45 Fasnachtsferien
Wednesday 11.03.2020 09.00-11.45 Gewerbestrasse 14, Vorlesungsraum DBE 14.03.002
Wednesday 18.03.2020 09.00-11.45 Gewerbestrasse 14, --
Wednesday 25.03.2020 09.00-11.45 Gewerbestrasse 14, --
Wednesday 01.04.2020 09.00-11.45 Gewerbestrasse 14, --
Wednesday 08.04.2020 09.00-11.45 Gewerbestrasse 14, --
Wednesday 15.04.2020 09.00-11.45 Gewerbestrasse 14, --
Wednesday 22.04.2020 09.00-11.45 Gewerbestrasse 14, --
Wednesday 29.04.2020 09.00-11.45 Gewerbestrasse 14, --
Wednesday 06.05.2020 09.00-11.45 Gewerbestrasse 14, --
Wednesday 13.05.2020 09.00-11.45 Gewerbestrasse 14, --
Wednesday 20.05.2020 09.00-11.45 Gewerbestrasse 14, --
Wednesday 27.05.2020 09.00-11.45 Gewerbestrasse 14, --
Modules Doctorate Biomedical Engineering: Recommendations (PhD subject Biomedical Engineering)
Module: Biomaterials Science and Nanotechnology (Master's Studies: Biomedical Engineering)
Module: Image-Guided Therapy (Master's Studies: Biomedical Engineering)
Assessment format proof of course participation
Assessment details Attendance 25%, Practical Work 20%, Quiz 15% and Final oral Exam 40%.
Assessment registration/deregistration Reg./dereg.: course registr./cancel registr. via MOnA
Repeat examination one repetition, best attempt counts
Scale 1-6 0,5
Repeated registration as often as necessary
Responsible faculty Faculty of Medicine
Offered by Departement Biomedical Engineering (DBE)