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| Semester | Frühjahrsemester 2018 |
| Angebotsmuster | Jedes Frühjahrsem. |
| Dozierende | Josef Gut (joseph.gut@unibas.ch, BeurteilerIn) |
| Inhalt | Basics Genetic polymorphisms; allelic variants; haplotypes; genotypes; phenotypes; allelic frequencies; ethnic group frequencies: Odds-ratio; positive predictive factors; negative predictive factors; genome-wide association studies; expression priofiles; etc. Pharmaco- /Toxicogenetics Pharmacogenetics in clinical setting; personalized medicine; gene-based dosie selection/adjustement; gene-based patient selection; companion tests. Expression genetics Gene expression profiles in cellular systems; gene expression profiles in preclinical animal models; gene expression proflles in the clinical staging of diseases and/or disease outcome under selected therapy regimen; realization of diagnostic tests. |
| Lernziele | The students understand the basic principles of pharmaco- and toxicogenomics. They also understand the concepts of pharmaco- and toxicogenetics and of expression genetics. The students understand the meaning of the correlation of genotype (or haplotype) and phenotype and corresponding tests aiming at optimizing of drug therapies. The students know a selection of important genes (and their most frequent allelic variants) which play major roles as efficacy targets for selected therapies, as targets of impaired drug disposition, and as targets for predispositions of patients for serious adverse drug effects. The students understand the meaning of expression profiles and, based on selected examples, the use of such profiles in the preclinical and clinical development of drugs as well as in the prediction of disease progression and/or therapy outcomes. The students understand the meaning of selected alleles and/or their expressed protein variants as biomarkers and their usage in as diagnostics in the approval process of new therapeutics. |
| Literatur | Will be announced at the beginning of the course |
| Bemerkungen | Power-Point Folien der Vorlesung werden auf der Webseite der Abteilung für Molekular- und Systemtoxikologie zugänglich sein. Film and sound recordings during the course are strictly forbidden (recorders may be confiscated |
| Unterrichtssprache | Englisch |
| Einsatz digitaler Medien | kein spezifischer Einsatz |
| Intervall | Wochentag | Zeit | Raum |
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Keine Einzeltermine verfügbar, bitte informieren Sie sich direkt bei den Dozierenden.
| Module |
Modul Specific Knowledge in Toxicology (Master Toxikologie (Studienbeginn vor 01.08.2016)) (Pflicht) Modul Translating Pharmacology and Drug Safety to Humans (Master Drug Sciences) Vertiefungsmodul Pharmakologie (Master Pharmazeutische Wissenschaften (Studienbeginn vor 01.08.2016)) Vertiefungsmodul Toxikologie (Master Pharmazeutische Wissenschaften (Studienbeginn vor 01.08.2016)) Wahlbereich Master Pharmazie: Empfehlungen (Master Pharmazie) |
| Leistungsüberprüfung | Lehrveranst.-begleitend |
| Hinweise zur Leistungsüberprüfung | Please refer to the list: https://pharma.unibas.ch/de/teaching/pruefungen-exams/performance-assessments/course-accompanying-examinations/ |
| An-/Abmeldung zur Leistungsüberprüfung | Anm.: Belegen Lehrveranstaltung; Abm.: stornieren |
| Wiederholungsprüfung | keine Wiederholungsprüfung |
| Skala | Pass / Fail |
| Wiederholtes Belegen | beliebig wiederholbar |
| Zuständige Fakultät | Philosophisch-Naturwissenschaftliche Fakultät, studiendekanat-philnat@unibas.ch |
| Anbietende Organisationseinheit | Departement Pharmazeutische Wissenschaften |