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29954-01 - Vorlesung: Food Toxicology and Risk Assessment 1 KP

Semester Frühjahrsemester 2019
Angebotsmuster Jedes Frühjahrsem.
Dozierende Hanspeter Nägeli (h.naegeli@unibas.ch, BeurteilerIn)
Inhalt This lecture presents the current state of the science of risk assessment of chemicals (additives, pesticide or drug residues, phytochemicals, toxins and contaminants) in food by consideration of the four stages of risk assessment, i.e., hazard identification, hazard characterization, exposure assessment and risk characterization. The contribution of animal-based methods and pharmacologic or epidemiologic studies will be outlined with emphasis on the importance of first applying existing chemical, biochemical, physiologic or toxicological knowledge. The lecture will also discuss the issues of risk management and communication in food toxicology, identify gaps of knowledge and outline areas of current research.

Specific topics:
Introduction – Historical background, legal basis, acute threats and pervasive low-level exposures
Tools of risk assessment and management – NOEL, ADI/TDI, BMD & MOE concepts, examples of MLs & MRLs
Residue toxicology – Pesticides & veterinary drugs
Analytical guidelines – screening & confirmatory methods, interpretation of results
The concept of “threshold of toxicological concern” with reference to food
Carcinogens in food (including toxicants induced during food processing)
Toxicologic assessment of genetically modified food
Anthropogenic contaminants – POPs, heavy metals
Phytochemicals in food
Mycotoxins in food
Dietary chemoprotection
Emerging issues in food toxicology – Case studies
Lernziele Understand methods of risk assessment of chemicals in food, application to current issues in food toxicology, knowledge of major food-borne chemical hazards
Literatur Watson DH (2004) Pesticide, veterinary and other residues in food. Woodhead Publishing, CRC Prss, Boca Raton

Different opinions published by EFSA (European Food Safety Authority)
Bemerkungen Film and sound recordings during the course are strictly forbidden (recorders may be confiscated


Unterrichtssprache Englisch
Weblink ADAM
Einsatz digitaler Medien kein spezifischer Einsatz


Intervall wöchentlich
Datum 19.02.2019 – 09.04.2019
Zeit Dienstag, 10.15-12.00 Biozentrum, Seminarraum 104
Datum Zeit Raum
Dienstag 19.02.2019 10.15-12.00 Uhr Biozentrum, Seminarraum 104
Dienstag 26.02.2019 10.15-12.00 Uhr Biozentrum, Seminarraum 104
Dienstag 05.03.2019 10.15-12.00 Uhr Biozentrum, Seminarraum 104
Dienstag 12.03.2019 10.15-12.00 Uhr Fasnachtsferien
Dienstag 19.03.2019 10.15-12.00 Uhr Biozentrum, Seminarraum 104
Dienstag 26.03.2019 10.15-12.00 Uhr Biozentrum, Seminarraum 104
Dienstag 02.04.2019 10.15-12.00 Uhr Biozentrum, Seminarraum 104
Dienstag 09.04.2019 10.15-12.00 Uhr Biozentrum, Seminarraum 104
Module Wahlbereich Master Drug Sciences: Empfehlungen (Masterstudium: Drug Sciences)
Wahlbereich Master Pharmazie: Empfehlungen (Masterstudium: Pharmazie)
Leistungsüberprüfung Lehrveranst.-begleitend
Hinweise zur Leistungsüberprüfung Please refer to the list: https://pharma.unibas.ch/de/teaching/pruefungen-exams/performance-assessments/course-accompanying-examinations/
An-/Abmeldung zur Leistungsüberprüfung An-/Abmelden: Belegen resp. Stornieren der Belegung via MOnA
Wiederholungsprüfung keine Wiederholungsprüfung
Skala 1-6 0,5
Wiederholtes Belegen beliebig wiederholbar
Zuständige Fakultät Philosophisch-Naturwissenschaftliche Fakultät, studiendekanat-philnat@unibas.ch
Anbietende Organisationseinheit Departement Pharmazeutische Wissenschaften