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29955-01 - Vorlesung: Immunosafety 1 KP

Semester Frühjahrsemester 2020
Angebotsmuster Jedes Frühjahrsem.
Dozierende Andreas J. Bircher (andreas.bircher@unibas.ch)
Tobias Manigold (tobias.manigold@unibas.ch)
Thomas Singer (thomas.singer@unibas.ch)
Daniel Yerly (daniel.yerly@unibas.ch)
Inhalt Principles of the immune system; Immunotoxicology of drugs; Immunosafety of biopharmaceuticals (T. Singer)
Immunosafety risk assessment; Immunosafety toolbox; Risk mitigation strategy (T. Singer)
Principles of T cell stimulation by hapten, prohapten, pi-concept and HLA restricted relations (D. Yerly)
Immune reactions to biologicals: principles and clinic; Drugs and antibody productions: IgE mediated reactons (the penicilin model); anaphylaxis, cross-reactivity, pholcodin model (T. Manigold)
Immun reactions to biologicals: infusion reactions and cytokine release syndromes: risk assessment. Type II and III reactions (haemolytic anaemia, agranulo-cytosis, throbocytopenia, ...) (T. Manigold)
Drugs and the skin: toxicity & contact dermatitis (T. Singer)
Drugs and the skin: cutaneous reactions (MPE, SJS/TEN, AGEP) (A. Bircher)
Risk assessment in drug hypersensitivity - in vivo or in vitro? Is it possible? Examples (M. Kammüller)
Diagnosis of drug hypersensitivity: skin tests, provocation tests, in vitro tests for drug hypersensitivity (A. Bircher)
Examination (T. Singer)
Lernziele The basic principles of immunology should be known by the participants.
Know the principles of immunotoxicological hazard identification and risk assessment of drugs.
Know the basics of drug-induced hypersensitivity.
Understand IgE mediated reactions against drugs.
understand the basics of infusion reactions and cytokine release syndromes.
Know the basics of skin reactions against drugs.
Literatur Peter J. Delves, Seamus J. Martin, Dennis R. Burton, Ivan M. Roitt: Roitt's Essential Immunology; 13th Edition; Wiley-Blackwell; 2017
Bemerkungen Film and sound recordings during the course are strictly forbidden (recorders may be confiscated)
Weblink ADAM

 

Unterrichtssprache Englisch
Einsatz digitaler Medien kein spezifischer Einsatz

 

Intervall wöchentlich
Datum 18.02.2020 – 07.04.2020
Zeit Dienstag, 13.15-15.00 Biozentrum, Seminarraum 104
Datum Zeit Raum
Dienstag 18.02.2020 13.15-15.00 Uhr Biozentrum, Seminarraum 104
Dienstag 25.02.2020 13.15-15.00 Uhr Biozentrum, Seminarraum 104
Dienstag 03.03.2020 13.15-15.00 Uhr Fasnachtsferien
Dienstag 10.03.2020 13.15-15.00 Uhr Biozentrum, Seminarraum 104
Dienstag 17.03.2020 13.15-15.00 Uhr Biozentrum, Seminarraum 104
Dienstag 24.03.2020 13.15-15.00 Uhr Biozentrum, Seminarraum 104
Dienstag 31.03.2020 13.15-15.00 Uhr Biozentrum, Seminarraum 104
Dienstag 07.04.2020 13.15-15.00 Uhr Biozentrum, Seminarraum 104
Module Modul: Translating Pharmacology and Drug Safety to Humans (Masterstudium: Drug Sciences)
Wahlbereich Master Pharmazie: Empfehlungen (Masterstudium: Pharmazie)
Leistungsüberprüfung Lehrveranst.-begleitend
Hinweise zur Leistungsüberprüfung Please refer to the list: https://pharma.unibas.ch/de/teaching/pruefungen-exams/performance-assessments/course-accompanying-examinations/
An-/Abmeldung zur Leistungsüberprüfung An-/Abmelden: Belegen resp. Stornieren der Belegung via MOnA
Wiederholungsprüfung keine Wiederholungsprüfung
Skala 1-6 0,5
Wiederholtes Belegen beliebig wiederholbar
Zuständige Fakultät Philosophisch-Naturwissenschaftliche Fakultät, studiendekanat-philnat@unibas.ch
Anbietende Organisationseinheit Departement Pharmazeutische Wissenschaften

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