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| Semester | Herbstsemester 2020 |
| Angebotsmuster | Jedes Herbstsemester |
| Dozierende |
Hubert Hug (hubert.hug@dsm.com)
Alex Odermatt (alex.odermatt@unibas.ch, BeurteilerIn) Maria Tsachaki (maria.tsachaki@unibas.ch) |
| Inhalt | General aspects of carcinogenesis (A. Odermatt) Mechanisms of mutagenesis and carcinogenesis (M. Tsachaki) The role of oncogenes in cancer (M. Tsachaki) Tumor suppressors (M. Tsachaki) Macroscopic genetic alterations and cancer predisposition (M. Tsachaki) Toxicogenomics (H. Hug) Animal models to detect carcinogens (Ph. Bentley) Transgenic animal models used in carcinogenicity (H.-J. Martus) Genotoxicity and carcinogenicity (P. Sagelsdorff) Anticarcinogenesis (H. Nägeli) Targeted anticancer drugs (P. Manley) Tumor models in cancer therapy (M.R. Jensen) Estrogen- and androgen-dependent tumors (A. Odermatt) Treatment of estrogen- and androgen-dependent cancer (A. Odermatt) E-learning forum |
| Lernziele | To understand the basics of chemical induction of tumorigenesis. To know cancerogenic chemicals and their mechanisms of action. To understand defense mechanisms and the relevance of transport, phase I and phase II detoxification enzymes. To be able to name three oncogenes and tumor suppressor genes and explain their function in the cell. To know tests used in the detection of cancer cells and genetic predisposition. To know animal models used to detect cancerogenic chemicals and to know defense and repair mechanisms. To know chemotherapeutic drugs as well as the mechanisms involved in resistance to such drugs. |
| Literatur | Arzneimittelwirkungen kompakt. Basiswissen Pharmakologie und Toxikologie, Mutschler Allgemeine und spezielle Pharmakologie und Toxikologie, Aktories The Biology of Cancer, Robert A. Weinberg, Garland Science 2007 |
| Bemerkungen | active participation to the e-learning forum is required. Film and sound recordings during the course are strictly forbidden (recorders may be confiscated) |
| Weblink | ADAM |
| Teilnahmebedingungen | Completed Bachelor degree |
| Unterrichtssprache | Englisch |
| Einsatz digitaler Medien | kein spezifischer Einsatz |
| Intervall | Wochentag | Zeit | Raum |
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Keine Einzeltermine verfügbar, bitte informieren Sie sich direkt bei den Dozierenden.
| Module |
Modul: Introduction and Basis of Human Diseases (Masterstudium: Drug Sciences) Wahlbereich Master Pharmazie: Empfehlungen (Masterstudium: Pharmazie) |
| Leistungsüberprüfung | Lehrveranst.-begleitend |
| Hinweise zur Leistungsüberprüfung | Electronic written exam (Multiple Choice) https://pharma.unibas.ch/en/education/assessments-and-credit-points/continuous-assessments/ |
| An-/Abmeldung zur Leistungsüberprüfung | Anm.: Belegen Lehrveranstaltung; Abm.: stornieren |
| Wiederholungsprüfung | keine Wiederholungsprüfung |
| Skala | 1-6 0,5 |
| Wiederholtes Belegen | beliebig wiederholbar |
| Zuständige Fakultät | Philosophisch-Naturwissenschaftliche Fakultät, studiendekanat-philnat@unibas.ch |
| Anbietende Organisationseinheit | Departement Pharmazeutische Wissenschaften |