Zurück
| Semester | Frühjahrsemester 2022 |
| Angebotsmuster | Jedes Frühjahrsem. |
| Dozierende |
Andreas J. Bircher (andreas.bircher@unibas.ch)
Tobias Manigold (tobias.manigold@unibas.ch) Alex Odermatt (alex.odermatt@unibas.ch, BeurteilerIn) Thomas Singer (thomas.singer@unibas.ch) Daniel Yerly (daniel.yerly@unibas.ch) |
| Inhalt | Principles of the immune system; Immunotoxicology of drugs; Immunosafety of biopharmaceuticals (T. Singer) Immunosafety risk assessment; Immunosafety toolbox; Risk mitigation strategy (T. Singer) Principles of T cell stimulation by hapten, prohapten, pi-concept and HLA restricted relations (D. Yerly) Immune reactions to biologicals: principles and clinic; Drugs and antibody productions: IgE mediated reactons (the penicilin model); anaphylaxis, cross-reactivity, pholcodin model (T. Manigold) Immun reactions to biologicals: infusion reactions and cytokine release syndromes: risk assessment. Type II and III reactions (haemolytic anaemia, agranulo-cytosis, throbocytopenia, ...) (T. Manigold) Drugs and the skin: toxicity & contact dermatitis (T. Singer) Drugs and the skin: cutaneous reactions (MPE, SJS/TEN, AGEP) (A. Bircher) Risk assessment in drug hypersensitivity - in vivo or in vitro? Is it possible? Examples (M. Kammüller) Diagnosis of drug hypersensitivity: skin tests, provocation tests, in vitro tests for drug hypersensitivity (A. Bircher) Examination (T. Singer) |
| Lernziele | The basic principles of immunology should be known by the participants. Know the principles of immunotoxicological hazard identification and risk assessment of drugs. Know the basics of drug-induced hypersensitivity. Understand IgE mediated reactions against drugs. understand the basics of infusion reactions and cytokine release syndromes. Know the basics of skin reactions against drugs. |
| Literatur | Peter J. Delves, Seamus J. Martin, Dennis R. Burton, Ivan M. Roitt: Roitt's Essential Immunology; 13th Edition; Wiley-Blackwell; 2017 |
| Bemerkungen | Film and sound recordings during the course are strictly forbidden (recorders may be confiscated) |
| Weblink | Department of Pharmaceutical Sciences |
| Teilnahmebedingungen | Completed Bachelor degree |
| Unterrichtssprache | Englisch |
| Einsatz digitaler Medien | kein spezifischer Einsatz |
| Intervall | Wochentag | Zeit | Raum |
|---|---|---|---|
| wöchentlich | Dienstag | 13.15-15.00 | Pharmazentrum, Sitzungszimmer 1067 |
| Bemerkungen | Seminar room remains reserved for students of this lecture. |
| Datum | Zeit | Raum |
|---|---|---|
| Dienstag 22.02.2022 | 13.15-15.00 Uhr | Pharmazentrum, Findet online statt |
| Dienstag 01.03.2022 | 13.15-15.00 Uhr | Pharmazentrum, Findet online statt |
| Dienstag 08.03.2022 | 13.15-15.00 Uhr | Fasnachtsferien |
| Dienstag 15.03.2022 | 13.15-15.00 Uhr | Pharmazentrum, Findet online statt |
| Dienstag 22.03.2022 | 13.15-15.00 Uhr | Pharmazentrum, Findet online statt |
| Dienstag 29.03.2022 | 13.15-15.00 Uhr | Biozentrum, Seminarraum U1.191 |
| Dienstag 05.04.2022 | 13.15-15.00 Uhr | Pharmazentrum, Findet online statt |
| Module |
Modul: Translating Pharmacology and Drug Safety to Humans (Masterstudium: Drug Sciences) Modul: Vertiefung Medizinische Nanowissenschaften (Masterstudium: Nanowissenschaften) Wahlbereich Master Pharmazie: Empfehlungen (Masterstudium: Pharmazie) |
| Leistungsüberprüfung | Lehrveranst.-begleitend |
| Hinweise zur Leistungsüberprüfung | Please refer to the list: https://pharma.unibas.ch/en/education/assessments-and-credit-points/continuous-assessments/ |
| An-/Abmeldung zur Leistungsüberprüfung | Anm.: Belegen Lehrveranstaltung; Abm.: stornieren |
| Wiederholungsprüfung | keine Wiederholungsprüfung |
| Skala | 1-6 0,5 |
| Wiederholtes Belegen | beliebig wiederholbar |
| Zuständige Fakultät | Philosophisch-Naturwissenschaftliche Fakultät, studiendekanat-philnat@unibas.ch |
| Anbietende Organisationseinheit | Departement Pharmazeutische Wissenschaften |