Zur Merkliste hinzufügen
Zurück

 

21470-01 - Vorlesung: Pharmacogenomics 1 KP

Semester Frühjahrsemester 2022
Angebotsmuster Jedes Frühjahrsem.
Dozierende Josef Gut (joseph.gut@unibas.ch, BeurteilerIn)
Inhalt Basics Genetic polymorphisms; allelic variants; haplotypes; genotypes; phenotypes; allelic frequencies; ethnic group frequencies: Odds-ratio; positive predictive factors; negative predictive factors; genome-wide association studies; expression priofiles; etc. Pharmaco- /Toxicogenetics Pharmacogenetics in clinical setting; personalized medicine; gene-based dosie selection/adjustement; gene-based patient selection; companion tests. Expression genetics Gene expression profiles in cellular systems; gene expression profiles in preclinical animal models; gene expression proflles in the clinical staging of diseases and/or disease outcome under selected therapy regimen; realization of diagnostic tests.
Lernziele The students understand the basic principles of pharmaco- and toxicogenomics. They also understand the concepts of pharmaco- and toxicogenetics and of expression genetics. The students understand the meaning of the correlation of genotype (or haplotype) and phenotype and corresponding tests aiming at optimizing of drug therapies. The students know a selection of important genes (and their most frequent allelic variants) which play major roles as efficacy targets for selected therapies, as targets of impaired drug disposition, and as targets for predispositions of patients for serious adverse drug effects. The students understand the meaning of expression profiles and, based on selected examples, the use of such profiles in the preclinical and clinical development of drugs as well as in the prediction of disease progression and/or therapy outcomes. The students understand the meaning of selected alleles and/or their expressed protein variants as biomarkers and their usage in as diagnostics in the approval process of new therapeutics.
Literatur Will be announced at the beginning of the course
Bemerkungen Power-Point Folien der Vorlesung werden auf der Webseite der Abteilung für Molekular- und Systemtoxikologie zugänglich sein.
Film and sound recordings during the course are strictly forbidden (recorders may be confiscated
Weblink Department of Pharmaceutical Sciences

 

Teilnahmebedingungen Completed Bachelor degree
Unterrichtssprache Englisch
Einsatz digitaler Medien kein spezifischer Einsatz

 

Intervall wöchentlich
Datum 23.02.2022 – 13.04.2022
Zeit Mittwoch, 15.15-17.00 Biozentrum, Seminarraum U1.197

Seminar room U1.197 remains reserved for students of this lecture.

Datum Zeit Raum
Mittwoch 23.02.2022 15.15-17.00 Uhr Biozentrum, Findet online statt
Mittwoch 02.03.2022 15.15-17.00 Uhr Biozentrum, Findet online statt
Mittwoch 09.03.2022 15.15-17.00 Uhr Fasnachtsferien
Mittwoch 16.03.2022 15.15-17.00 Uhr Biozentrum, Findet online statt
Mittwoch 23.03.2022 15.15-17.00 Uhr Biozentrum, Findet online statt
Mittwoch 30.03.2022 15.15-17.00 Uhr Biozentrum, Findet online statt
Mittwoch 06.04.2022 15.15-17.00 Uhr Biozentrum, Findet online statt
Mittwoch 13.04.2022 15.15-17.00 Uhr Biozentrum, Findet online statt
Module Modul: Translating Pharmacology and Drug Safety to Humans (Masterstudium: Drug Sciences)
Modul: Vertiefung Medizinische Nanowissenschaften (Masterstudium: Nanowissenschaften)
Wahlbereich Master Pharmazie: Empfehlungen (Masterstudium: Pharmazie)
Leistungsüberprüfung Lehrveranst.-begleitend
Hinweise zur Leistungsüberprüfung Group work and online presentations (details will be communicated during the lecture).
An-/Abmeldung zur Leistungsüberprüfung An-/Abmelden: Belegen resp. Stornieren der Belegung via MOnA
Wiederholungsprüfung keine Wiederholungsprüfung
Skala Pass / Fail
Wiederholtes Belegen beliebig wiederholbar
Zuständige Fakultät Philosophisch-Naturwissenschaftliche Fakultät, studiendekanat-philnat@unibas.ch
Anbietende Organisationseinheit Departement Pharmazeutische Wissenschaften

Zurück