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70408-01 - Vorlesung: Applied Methods in Forensic Genetics and Forensic Toxicology 3 KP

Semester Herbstsemester 2024
Angebotsmuster Jedes Herbstsemester
Dozierende Urs Duthaler (urs.duthaler@unibas.ch)
Götz Schlotterbeck (g.schlotterbeck@unibas.ch)
Iris Schulz (iris.schulz@unibas.ch, BeurteilerIn)
Inhalt Course contents Forensic Toxicology:
Theme 1 Analytical methods in Forensic Toxicology (2h)
• Analytical tools: LC-MS/MS, GC-MS/MS, Immunoassays…
• Advantages and limitations
Theme 2 Driving under the influence of alcohol and drugs (4h)
• Biological matrices, sample preparation and measurement
• Blood alcohol, limits, regulations
• Relevant drugs, limit substances
Theme 3 Hair analysis (2h)
• Dealing with hair samples in the forensic context
• Application of hair testing in abstinence control and crime case works
Theme 4 New psychoactive substances (NPS) and knockout substances (2h)
• Analytical tools to assess various compound classes
• Case studies

Forensic Genetics:
Theme 1 Biological basis and current applied DNA analysis (4h)
• Tasks of forensic genetics: trace, relationship and identification analyses
• Human genome, structure and polymorphism; autosomal and gonosomal DNA short tandem repeats
• DNA analysis methods: Immunological pre-tests, microscopy, staining, and differential lysis (DL), extraction, amplification and capillary electrophoresis, profile interpretation (biostatistics, database), law
• RNA markers and mtDNA sequencing and their applications
Theme 2 Specific DNA and RNA applications (3h)
• Single cell isolation: Laser-Capture Microdissection (LCM), DEPArray and microfluidic principles, Flow-Cytometry (DEPArray)
• Benefits and limits of classical (DL, LCM) and state-of-the-art technologies
• RNA profiling and body fluid identification
Theme 3 Future Methods (3h)
• Principle of DNA sequencing
• Pyrosequencing and Next Generation Sequencing
• Phenotyping, biogeographic and age estimation
Lernziele After completing the module, students will be able to…
• possess scientific knowledge of the fundamental principles underlying forensic toxicology and forensic genetics.
• know state-of-the-art technologies and future trends in forensic toxicological and forensic genetic methods, including their advances and limitations.
• apply acquired knowledge to use existing instrumentations and techniques in forensic practices, and contribute to the development of new methodologies.
• can clearly, effectively and concisely present their results to peers as well as to the public in written and oral form according to scientific standards.

 

Teilnahmebedingungen The course is designed for students holding a Bachelor’s degree of various backgrounds like engineering, natural sciences, computer sciences, medicine or health sciences
Unterrichtssprache Englisch
Einsatz digitaler Medien kein spezifischer Einsatz

 

Intervall Wochentag Zeit Raum
wöchentlich Mittwoch 08.15-10.00 Biozentrum, Seminarraum U1.193

Einzeltermine

Datum Zeit Raum
Mittwoch 18.09.2024 08.15-10.00 Uhr Biozentrum, Seminarraum U1.193
Mittwoch 25.09.2024 08.15-10.00 Uhr Biozentrum, Seminarraum U1.193
Mittwoch 02.10.2024 08.15-10.00 Uhr Biozentrum, Seminarraum U1.193
Mittwoch 09.10.2024 08.15-10.00 Uhr Biozentrum, Seminarraum U1.193
Mittwoch 16.10.2024 08.15-10.00 Uhr Biozentrum, Seminarraum U1.193
Mittwoch 23.10.2024 08.15-10.00 Uhr Biozentrum, Seminarraum U1.193
Mittwoch 30.10.2024 08.15-10.00 Uhr Biozentrum, Seminarraum U1.193
Mittwoch 06.11.2024 08.15-10.00 Uhr Biozentrum, Seminarraum U1.193
Mittwoch 13.11.2024 08.15-10.00 Uhr Biozentrum, Seminarraum U1.193
Mittwoch 20.11.2024 08.15-10.00 Uhr Biozentrum, Seminarraum U1.193
Mittwoch 27.11.2024 08.15-10.00 Uhr Biozentrum, Seminarraum U1.193
Mittwoch 04.12.2024 08.15-10.00 Uhr Biozentrum, Seminarraum U1.193
Mittwoch 11.12.2024 08.15-10.00 Uhr Biozentrum, Seminarraum U1.193
Mittwoch 18.12.2024 08.15-10.00 Uhr Biozentrum, Seminarraum U1.193
Module Modul: Image Acquisition and Analysis (Masterstudium: Biomedical Engineering)
Modul: Vertiefung Medizinische Nanowissenschaften (Masterstudium: Nanowissenschaften)
Leistungsüberprüfung Leistungsnachweis
Hinweise zur Leistungsüberprüfung • Presentation on selected topics of 10 minutes on last lecture blocks, groups of 2 (50%)
• Written outline of presentation, including literature study (50%)
An-/Abmeldung zur Leistungsüberprüfung Anm.: Belegen Lehrveranstaltung; Abm.: stornieren
Wiederholungsprüfung eine Wiederholung, bester Versuch zählt
Skala 1-6 0,1
Wiederholtes Belegen beliebig wiederholbar
Zuständige Fakultät Medizinische Fakultät
Anbietende Organisationseinheit Departement Biomedical Engineering (DBE)

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