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13186-01 - Vorlesung: Frontiers in RNA Biology (2 KP)
| Semester | Herbstsemester 2014 |
| Angebotsmuster | Jedes 2. Herbstsem. |
| Dozierende |
Marc Bühler (marc.buehler@unibas.ch, BeurteilerIn)
Rafal Ciosk (rafal.ciosk@unibas.ch) Helge Grosshans (helge.grosshans@unibas.ch) |
| Inhalt | Content:This course will cover a broad spectrum of RNA related topics. Local and outside lecturers who are leaders in their respective fields will teach the course. Each topic will be introduced by 45-minute general lecture followed by a more specific, traditional research seminar highlighting the latest results of the lecturers laboratory. 25.09. RNA: molecule for all seasons Witek Filipowicz / 02.10. no lecture / 09.10. RNA quality control/decay Georg Stöcklin / 16.10. mRNA translation Rafal Ciosk / 23.10. RNA localization Jeff Chao / 30.10. Structure of RNA-protein interactions Fred Allain / 06.11. miRNAs and RNAi Helge Grosshans Room 5.39 / 13.11. mRNA processing Herve le Hir / 20.11. RNA-based defense mechanisms in prokaryotes Martin Jinek / 27.11. Small RNAs in eukaryotic genome regulation Marc Bühler / 04.12. RNA-omics Jernei Ule / 11.12. small RNA biology and PTGS in plants Fred Meins / 18.12. RNA therapeutics Jonathan Hall |
| Literatur | The discovery that RNA is not only a carrier of genetic information or a structural scaffold in ribonucleoprotein particles but can also act as a catalyst in many different cellular processes, greatly stimulated research on the structure, processing and function of RNA. The lecture will cover the following topics: chemistry and structure of RNA; major classes of cellular RNAs (mRNAs, tRNAs, rRNAs, snRNAs, and the newly discovered small regulatory ~20-nt RNAs); chemistry and structure of RNA; pre-mRNA processing with emphasis on splicing and polyadenylation; biogenesis of tRNA and rRNA; biochemistry and function of RNA interference (RNAi) and microRNAs; RNA trafficking in the cell, RNA quality control and RNA degradation; and regulated mRNA translation during development. Also covered are RNA-protein interactions and major classes of ribonucleoprotein particles and the evolution of RNAs. 25.09. RNA: molecule for all seasons Witek Filipowicz 02.10. no lecture 09.10. RNA quality control/decay Georg Stöcklin 16.10. mRNA translation Rafal Ciosk 23.10. RNA localization Jeff Chao 30.10. Structure of RNA-protein interactions Fred Allain 06.11. miRNAs and RNAi Helge Grosshans 13.11. mRNA processing Herve le Hir 20.11. RNA-based defense mechanisms in prokaryotes Martin Jinek 27.11. Small RNAs in eukaryotic genome regulation Marc Bühler 04.12. RNA-omics Jernei Ule 11.12. small RNA biology and PTGS in plants Fred Meins 18.12. RNA therapeutics Jonathan Hall |
| Bemerkungen | http://www.biozentrum.unibas.ch/education/phd/graduate-program/cycle-g/ With Jeffrey Chao and invited lecturers. |
| Weblink | https://adam.unibas.ch |
| Unterrichtssprache | Englisch |
| Einsatz digitaler Medien | Online-Angebot fakultativ |
| Intervall | Wochentag | Zeit | Raum |
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Keine Einzeltermine verfügbar, bitte informieren Sie sich direkt bei den Dozierenden.
| Module |
Cycle G: Gene Expression and Epigenetics (Promotionsfach: Biochemie) Cycle G: Gene Expression and Epigenetics (Promotionsfach: Biophysik) Cycle G: Gene Expression and Epigenetics (Promotionsfach: Genetik) Cycle G: Gene Expression and Epigenetics (Promotionsfach: Mikrobiologie) Cycle G: Gene Expression and Epigenetics (Promotionsfach: Zellbiologie) Cycle G: Gene Expression and Epigenetics (Promotionsfach: Pharmakologie) Cycle G: Gene Expression and Epigenetics (Promotionsfach: Neurobiologie) Cycle G: Gene Expression and Epigenetics (Promotionsfach: Bioinformatik) Cycle G: Gene Expression and Epigenetics (Promotionsfach: Strukturbiologie) Cycle G: Gene Expression and Epigenetics (Master Molekularbiologie) Modul Vertiefungsfach Molekularbiologie (Master Nanowissenschaften) |
| Prüfung | Lehrveranst.-begleitend |
| An-/Abmeldung zur Prüfung | Anmelden: Belegen; Abmelden: Dozierende |
| Wiederholungsprüfung | keine Wiederholungsprüfung |
| Skala | Pass / Fail |
| Belegen bei Nichtbestehen | beliebig wiederholbar |
| Zuständige Fakultät | Philosophisch-Naturwissenschaftliche Fakultät, studiendekanat-philnat@unibas.ch |
| Anbietende Organisationseinheit | Departement Biozentrum |