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29955-01 - Vorlesung: Immunosafety (1 KP)
| Semester | Frühjahrsemester 2025 |
| Angebotsmuster | Jedes Frühjahrsem. |
| Dozierende |
José Manuel Carballido Herrera (jose.carballido@unibas.ch)
Timothy Paul Hickling (timothypaul.hickling@unibas.ch) Alex Odermatt (alex.odermatt@unibas.ch, BeurteilerIn) Daniel Yerly (daniel.yerly@unibas.ch) |
| Inhalt | Principles of the immune system; Immunotoxicology of drugs; Immunosafety of biopharmaceuticals Immunosafety risk assessment; Immunosafety toolbox; Risk mitigation strategy Principles of T cell stimulation by hapten, prohapten, pi-concept and HLA restricted relations Immune reactions to biologicals: principles and clinic; Drugs and antibody productions: IgE mediated reactons (the penicilin model); anaphylaxis, cross-reactivity, pholcodin model Immun reactions to biologicals: infusion reactions and cytokine release syndromes: risk assessment. Type II and III reactions (haemolytic anaemia, agranulo-cytosis, throbocytopenia, ...) Drugs and the skin: toxicity & contact dermatitis Drugs and the skin: cutaneous reactions (MPE, SJS/TEN, AGEP) Risk assessment in drug hypersensitivity - in vivo or in vitro? Is it possible? Examples Diagnosis of drug hypersensitivity: skin tests, provocation tests, in vitro tests for drug hypersensitivity |
| Lernziele | The basic principles of immunology should be known by the participants. Know the principles of immunotoxicological hazard identification and risk assessment of drugs. Know the basics of drug-induced hypersensitivity. Understand IgE mediated reactions against drugs. understand the basics of infusion reactions and cytokine release syndromes. Know the basics of skin reactions against drugs. |
| Literatur | Peter J. Delves, Seamus J. Martin, Dennis R. Burton, Ivan M. Roitt: Roitt's Essential Immunology; 13th Edition; Wiley-Blackwell; 2017 |
| Bemerkungen | Film and sound recordings during the course are strictly forbidden (recorders may be confiscated) |
| Weblink | Department of Pharmaceutical Sciences |
| Teilnahmevoraussetzungen | Completed Bachelor degree |
| Unterrichtssprache | Englisch |
| Einsatz digitaler Medien | kein spezifischer Einsatz |
| Intervall | Wochentag | Zeit | Raum |
|---|---|---|---|
| wöchentlich | Dienstag | 13.15-15.00 | Pharmazentrum, Hörsaal 2 |
Einzeltermine
| Datum | Zeit | Raum |
|---|---|---|
| Dienstag 18.02.2025 | 13.15-15.00 Uhr | Pharmazentrum, Hörsaal 2 |
| Dienstag 25.02.2025 | 13.15-15.00 Uhr | Pharmazentrum, Hörsaal 2 |
| Dienstag 04.03.2025 | 13.15-15.00 Uhr | Pharmazentrum, Hörsaal 2 |
| Dienstag 11.03.2025 | 13.15-15.00 Uhr | Fasnachstferien |
| Dienstag 18.03.2025 | 13.15-15.00 Uhr | Pharmazentrum, Hörsaal 2 |
| Dienstag 25.03.2025 | 13.15-15.00 Uhr | Pharmazentrum, Hörsaal 2 |
| Dienstag 01.04.2025 | 13.15-15.00 Uhr | Pharmazentrum, Hörsaal 2 |
| Dienstag 08.04.2025 | 13.15-15.00 Uhr | Pharmazentrum, Hörsaal 2 |
| Montag 14.04.2025 | 08.45-09.45 Uhr | Pharmazentrum, Hörsaal 1 |
| Module |
Modul: Translating Pharmacology and Drug Safety to Humans (Masterstudium: Drug Sciences) Modul: Vertiefung Medizinische Nanowissenschaften (Masterstudium: Nanowissenschaften) Wahlbereich Master Pharmazie: Empfehlungen (Masterstudium: Pharmazie) |
| Prüfung | Lehrveranst.-begleitend |
| Hinweise zur Prüfung | Please refer to the list: https://pharma.unibas.ch/en/education/assessments-and-credit-points/continuous-assessments/ |
| An-/Abmeldung zur Prüfung | Anm.: Belegen Lehrveranstaltung; Abm.: stornieren |
| Wiederholungsprüfung | keine Wiederholungsprüfung |
| Skala | 1-6 0,5 |
| Belegen bei Nichtbestehen | beliebig wiederholbar |
| Zuständige Fakultät | Philosophisch-Naturwissenschaftliche Fakultät, studiendekanat-philnat@unibas.ch |
| Anbietende Organisationseinheit | Departement Pharmazeutische Wissenschaften |