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70408-01 - Vorlesung: Applied Methods in Forensic Genetics and Forensic Toxicology (3 KP)
| Semester | Herbstsemester 2025 |
| Angebotsmuster | Jedes Herbstsemester |
| Dozierende |
Urs Duthaler (urs.duthaler@unibas.ch)
Götz Schlotterbeck (g.schlotterbeck@unibas.ch) Iris Schulz (iris.schulz@unibas.ch, BeurteilerIn) |
| Inhalt | Course contents Forensic Toxicology: Theme 1 Analytical methods in Forensic Toxicology (2h) • Analytical tools: LC-MS/MS, GC-MS/MS, Immunoassays… • Advantages and limitations Theme 2 Driving under the influence of alcohol and drugs (4h) • Biological matrices, sample preparation and measurement • Blood alcohol, limits, regulations • Relevant drugs, limit substances Theme 3 Hair analysis (2h) • Dealing with hair samples in the forensic context • Application of hair testing in abstinence control and crime case works Theme 4 New psychoactive substances (NPS) and knockout substances (2h) • Analytical tools to assess various compound classes • Case studies Forensic Genetics: Theme 1 Biological basis and current applied DNA analysis (4h) • Tasks of forensic genetics: trace, relationship and identification analyses • Human genome, structure and polymorphism; autosomal and gonosomal DNA short tandem repeats • DNA analysis methods: Immunological pre-tests, microscopy, staining, and differential lysis (DL), extraction, amplification and capillary electrophoresis, profile interpretation (biostatistics, database), law • RNA markers and mtDNA sequencing and their applications Theme 2 Specific DNA and RNA applications (3h) • Single cell isolation: Laser-Capture Microdissection (LCM), DEPArray and microfluidic principles, Flow-Cytometry (DEPArray) • Benefits and limits of classical (DL, LCM) and state-of-the-art technologies • RNA profiling and body fluid identification Theme 3 Future Methods (3h) • Principle of DNA sequencing • Pyrosequencing and Next Generation Sequencing • Phenotyping, biogeographic and age estimation |
| Lernziele | After completing the module, students will be able to… • possess scientific knowledge of the fundamental principles underlying forensic toxicology and forensic genetics. • know state-of-the-art technologies and future trends in forensic toxicological and forensic genetic methods, including their advances and limitations. • apply acquired knowledge to use existing instrumentations and techniques in forensic practices, and contribute to the development of new methodologies. • can clearly, effectively and concisely present their results to peers as well as to the public in written and oral form according to scientific standards. |
| Teilnahmevoraussetzungen | The course is designed for students holding a Bachelor’s degree of various backgrounds like engineering, natural sciences, computer sciences, medicine or health sciences |
| Unterrichtssprache | Englisch |
| Einsatz digitaler Medien | kein spezifischer Einsatz |
| Intervall | Wochentag | Zeit | Raum |
|---|---|---|---|
| wöchentlich | Mittwoch | 08.15-10.00 | Biozentrum, Seminarraum U1.195 |
Einzeltermine
| Datum | Zeit | Raum |
|---|---|---|
| Mittwoch 17.09.2025 | 08.15-10.00 Uhr | Biozentrum, Seminarraum U1.195 |
| Mittwoch 24.09.2025 | 08.15-10.00 Uhr | Biozentrum, Seminarraum U1.195 |
| Mittwoch 01.10.2025 | 08.15-10.00 Uhr | Biozentrum, Seminarraum U1.195 |
| Mittwoch 08.10.2025 | 08.15-10.00 Uhr | Biozentrum, Seminarraum U1.195 |
| Mittwoch 15.10.2025 | 08.15-10.00 Uhr | Biozentrum, Seminarraum U1.195 |
| Mittwoch 22.10.2025 | 08.15-10.00 Uhr | Biozentrum, Seminarraum U1.195 |
| Mittwoch 29.10.2025 | 08.15-10.00 Uhr | Biozentrum, Seminarraum U1.195 |
| Mittwoch 05.11.2025 | 08.15-10.00 Uhr | Biozentrum, Seminarraum U1.195 |
| Mittwoch 12.11.2025 | 08.15-10.00 Uhr | Biozentrum, Seminarraum U1.195 |
| Mittwoch 19.11.2025 | 08.15-10.00 Uhr | Biozentrum, Seminarraum U1.195 |
| Mittwoch 26.11.2025 | 08.15-10.00 Uhr | Biozentrum, Seminarraum U1.195 |
| Mittwoch 03.12.2025 | 08.15-10.00 Uhr | Biozentrum, Seminarraum U1.195 |
| Mittwoch 10.12.2025 | 08.15-10.00 Uhr | Biozentrum, Seminarraum U1.195 |
| Mittwoch 17.12.2025 | 08.15-10.00 Uhr | Biozentrum, Seminarraum U1.195 |
| Module |
Modul: Image Acquisition and Analysis (Masterstudium: Biomedical Engineering) Modul: Vertiefung Medizinische Nanowissenschaften (Masterstudium: Nanowissenschaften) |
| Prüfung | Leistungsnachweis |
| Hinweise zur Prüfung | • Presentation on selected topics of 10 minutes on last lecture blocks, groups of 2 (50%) • Written outline of presentation, including literature study (50%) |
| An-/Abmeldung zur Prüfung | Anm.: Belegen Lehrveranstaltung; Abm.: stornieren |
| Wiederholungsprüfung | eine Wiederholung, bester Versuch zählt |
| Skala | 1-6 0,1 |
| Belegen bei Nichtbestehen | beliebig wiederholbar |
| Zuständige Fakultät | Medizinische Fakultät |
| Anbietende Organisationseinheit | Departement Biomedical Engineering (DBE) |