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29955-01 - Vorlesung: Immunosafety (1 KP)
| Semester | Frühjahrsemester 2026 |
| Angebotsmuster | Jedes Frühjahrsem. |
| Dozierende |
José Manuel Carballido Herrera (jose.carballido@unibas.ch)
Alex Odermatt (alex.odermatt@unibas.ch, BeurteilerIn) Daniel Yerly (daniel.yerly@unibas.ch) |
| Inhalt | Principles of immunosafety; Immunotoxicology of drugs. Innate and adaptive immunity; Relevance of immune responses for drug immunosafety. Regulatory aspects and immunosafety requirements by clinical phases. Immunosafety risk assessment; Immunosafety toolbox. Hypersensitivity and adverse reactions to low molecular weight compounds; Mechanisms: haptens, pharmacologic interactions, altered peptide repertoires; Clinical manifestations: anaphylaxis, DRESS, serum sickness, contact dermatitis; Genetic predispositions: HLA alleles, drug-related triggers; Clinical diagnosis: Patient history, symptom timing, severity scales; Testing methods: Skin prick, intradermal, patch tests; IgE tests, basophil activation assays; LTT, cytokine release tests. New therapeutic modalities; Protein biologics: antibodies, antibody mimetics, enzymes and growth factors; RNA therapeutics: aptamers, antisense oligonucleotides, siRNA, mRNA, CRISPR-based genome editing; Cell and gene therapies: adeno-associated viral vectors, chimeric antigen receptors; Radioligands. Risk mitigation strategies: immune stimulatory effects of drugs, immune suppressive effects of drugs; Balancing effects of immunomodulators. Developing strategies to block immunogenicity: targeted delivery systems, immune tolerance. Real world workshop: case presentations, analysis and discussions |
| Lernziele | Ascertain the basic principles of immunology and immune reactivity to drugs. Learn the principles of immunotoxicological hazard and risk assessment of drugs. Understand drug-induced hypersensitivity and immunogenicity to established and new therapeutic modalities. Familiarize with mitigation strategies to prevent and treat immunogenicity reactions. Get insights into real-world immunogenicity situations. |
| Literatur | Peter J. Delves, Seamus J. Martin, Dennis R. Burton, Ivan M. Roitt: Roitt's Essential Immunology; 13th Edition; Wiley-Blackwell; 2017 |
| Bemerkungen | Film and sound recordings during the course are strictly forbidden (recorders may be confiscated) |
| Weblink | Department of Pharmaceutical Sciences |
| Teilnahmevoraussetzungen | Completed Bachelor degree |
| Unterrichtssprache | Englisch |
| Einsatz digitaler Medien | kein spezifischer Einsatz |
| Intervall | Wochentag | Zeit | Raum |
|---|---|---|---|
| wöchentlich | Dienstag | 13.15-15.00 | Pharmazentrum, Hörsaal 2 |
Einzeltermine
| Datum | Zeit | Raum |
|---|---|---|
| Dienstag 17.02.2026 | 13.15-15.00 Uhr | Pharmazentrum, Hörsaal 2 |
| Dienstag 24.02.2026 | 13.15-15.00 Uhr | Fasnachtsferien |
| Dienstag 03.03.2026 | 13.15-15.00 Uhr | Pharmazentrum, Hörsaal 2 |
| Dienstag 10.03.2026 | 13.15-15.00 Uhr | Pharmazentrum, Hörsaal 2 |
| Dienstag 17.03.2026 | 13.15-15.00 Uhr | Pharmazentrum, Hörsaal 2 |
| Dienstag 24.03.2026 | 13.15-15.00 Uhr | Pharmazentrum, Hörsaal 2 |
| Dienstag 31.03.2026 | 13.15-15.00 Uhr | Pharmazentrum, Hörsaal 2 |
| Dienstag 07.04.2026 | 13.15-15.00 Uhr | Pharmazentrum, Hörsaal 2 |
| Montag 20.04.2026 | 08.45-09.45 Uhr | Pharmazentrum, Hörsaal 1 |
| Module |
Modul: Translating Pharmacology and Drug Safety to Humans (Masterstudium: Drug Sciences) Modul: Vertiefung Medizinische Nanowissenschaften (Masterstudium: Nanowissenschaften) Wahlbereich Master Pharmazie: Empfehlungen (Masterstudium: Pharmazie) |
| Prüfung | Lehrveranst.-begleitend |
| Hinweise zur Prüfung | Please refer to the list: https://pharma.unibas.ch/en/education/assessments-and-credit-points/continuous-assessments/ |
| An-/Abmeldung zur Prüfung | Anm.: Belegen Lehrveranstaltung; Abm.: stornieren |
| Wiederholungsprüfung | keine Wiederholungsprüfung |
| Skala | 1-6 0,5 |
| Belegen bei Nichtbestehen | beliebig wiederholbar |
| Zuständige Fakultät | Philosophisch-Naturwissenschaftliche Fakultät, studiendekanat-philnat@unibas.ch |
| Anbietende Organisationseinheit | Departement Pharmazeutische Wissenschaften |