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24169-01 - Lecture with practical courses: E3: Computational Structural Biology (6 CP)
| Semester | spring semester 2011 |
| Course frequency | Every spring sem. |
| Lecturers |
Simon Bernèche (simon.berneche@unibas.ch)
Markus Meuwly (m.meuwly@unibas.ch) Torsten Schwede (torsten.schwede@unibas.ch, Assessor) |
| Content | The course will cover concepts of protein structure bioinformatics, modelling and simulation methods, their application to protein structures and their interactions with other molecules. In particular: protein structure comparison and classification, principles of molecular interactions, molecular mechanics simulations, in silico and structure based drug design, de novo and comparative protein modelling techniques. |
| Learning objectives | During the course, the students will gain: # In depth understanding of the theoretical concepts underlying modelling and simulation methods. The theoretical lectures are complemented by practical tasks, aiming to challenge the level of understanding of the students (e.g. programming low#level implementations of certain algorithms without using specific libraries or tool kits). # Experience in handling and manipulation of different three#dimensional representations and concepts, including: atomic coordinates, atomistic and molecular physico#chemical properties, molecular geometries, density maps, molecular descriptors. # Experience in the practical applications of modelling and simulation methods, and their limitations. Practical exercises involve critical evaluation / assessment of the confidence and accuracy of the applied methods. |
| Comments | mit Hans Joachim Böhm (hans-joachim.boehm@roche.com) |
| Weblink | http://www.biozentrum.unibas.ch/graduate |
| Admission requirements | Prerequisites: # Knowledge in structural biology, e.g. Bio4 ("Strukturbiologie") and Blockkurs or equivalent. # Basic programming skills |
| Language of instruction | English |
| Use of digital media | Online, optional |
| Interval | Weekday | Time | Room |
|---|
No dates available. Please contact the lecturer.
| Modules |
Cycle E: Computational and Systems Biology (PhD subject: Biochemistry) Cycle E: Computational and Systems Biology (PhD subject: Biophysics) Cycle E: Computational and Systems Biology (PhD subject: Genetics) Cycle E: Computational and Systems Biology (PhD subject: Microbiology) Cycle E: Computational and Systems Biology (PhD subject: Cell Biology) Cycle E: Computational and Systems Biology (PhD subject: Pharmacology) Cycle E: Computational and Systems Biology (PhD subject: Neurobiology) Cycle E: Computational and Systems Biology (PhD subject: Bioinformatics) Cycle E: Computational and Systems Biology (PhD subject: Structural Biology) Cycle E: Computational and Systems Biology (Master Molecular Biology) Module Specialisation: Molecular Biology (Master Nanosciences) |
| Assessment format | continuous assessment |
| Assessment registration/deregistration | Reg.: course registration; dereg.: teaching staff |
| Repeat examination | no repeat examination |
| Scale | Pass / Fail |
| Repeated registration | as often as necessary |
| Responsible faculty | Faculty of Science, studiendekanat-philnat@unibas.ch |
| Offered by | Departement Biozentrum |