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13185-01 - Lecture: E1: Genomics in Drug Discovery Research (2 CP)
| Semester | fall semester 2011 |
| Course frequency | Every fall sem. |
| Lecturers |
Paul L. Herrling (paul.herrling@unibas.ch, Assessor)
Torsten Schwede (torsten.schwede@unibas.ch) |
| Content | This course discusses the application of genomics research on drug discovery in the pharmaceutical industry. Integrated approaches of computational biology and bioinformatics have lately emerged as key disciplines for the application of human genome derived data to disease gene discovery and molecular epidemiology. These disciplines are increasingly important in the biopharmaceutical industry for the discovery of novel, more effective, and safer medicines. Schedule: Sept 20: Dominic Höpfner (Novartis Institute for Biomedical Research): Invertebrate models and functional genomics: Why study yeast for drug discovery? Sept 27: Pascal Mäser (STPH): From parasite genomes to drugs Oct 4: Frank Städtler (Novartis Institute for Biomedical Research): Analytical tools for genome wide analysis: arrays vs. next-generation sequencing. Oct 11: Daniel Hoyer, Novartis Institute for Biomedical Research: RNA interference and target validation in the brain Oct 18: Mihaela Zavolan (Biozentrum, Uni Basel): Principles of RNA interference Oct 25: Erik van Nimwegen (Biozentrum, Uni Basel): Computationally reconstructing transcription regulatory networks Nov 1: Michael Stadler (Friedrich Miescher Institute): From chromatin to RNA: Tag-based applications of next-generation sequencing Nov 8: Manuel Peitsch (Philip Morris International R&D): A network-based approach to quantify the impact of biologically active substances Nov 15: Dirk Schübele (Friedrich Miescher Institute): Functional epigenomics as a tool to study transcriptional regulation Nov 22: Dr. Isabel Filges and Prof. Peter Miny (UKBB): 1. Arrays in chromosome diagnostics. 2. Molecular genetic analyses in clinical genetic diagnostics: A (clinical) reality check Nov 29: Matthias Müller (Novartis Institute for Biomedical Research): The use of transgenic mice in pharmaceutical industry Dec 6: Peter Grass (Novartis Institute for Biomedical Research): Principles of study design of genomic experiments Dec 13: Caroline Gubser Keller (Novartis Institute for Biomedical Research): Genomics and data mining in early drug discovery: therapeutic target identification Dec 20: Karin Blumer (Novartis Switzerland): Do not harm - the moral dilemma of animal research in the life sciences |
| Comments | Organisation: Laura Viviani und Prof. Dr. T. Schwede |
| Weblink | http://www.biozentrum.unibas.ch/fileadmi |
| Language of instruction | English |
| Use of digital media | Online, optional |
| Interval | Weekday | Time | Room |
|---|
No dates available. Please contact the lecturer.
| Modules |
Cycle E: Computational and Systems Biology (PhD subject: Biochemistry) Cycle E: Computational and Systems Biology (PhD subject: Biophysics) Cycle E: Computational and Systems Biology (PhD subject: Genetics) Cycle E: Computational and Systems Biology (PhD subject: Microbiology) Cycle E: Computational and Systems Biology (PhD subject: Cell Biology) Cycle E: Computational and Systems Biology (PhD subject: Pharmacology) Cycle E: Computational and Systems Biology (PhD subject: Neurobiology) Cycle E: Computational and Systems Biology (PhD subject: Bioinformatics) Cycle E: Computational and Systems Biology (PhD subject: Structural Biology) Cycle E: Computational and Systems Biology (Master Molecular Biology) Module Specialisation: Molecular Biology (Master Nanosciences) |
| Assessment format | continuous assessment |
| Assessment details | At least 85% attendance is required, in addition to a written summary of a chosen lecture (2-3 A4 pages) to be handed in until December 21st, 2011, preferably as pdf by email to sarah.guethe@unibas.ch. |
| Assessment registration/deregistration | Reg.: course registration; dereg.: teaching staff |
| Repeat examination | no repeat examination |
| Scale | Pass / Fail |
| Repeated registration | as often as necessary |
| Responsible faculty | Faculty of Science, studiendekanat-philnat@unibas.ch |
| Offered by | Departement Biozentrum |