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13182-01 - Lecture: C2: Functional Organization of the Cell Nucleus (2 CP)
| Semester | fall semester 2012 |
| Course frequency | Every 2nd fall sem. |
| Lecturers |
Susan Gasser (susan.gasser@unibas.ch, Assessor)
Erich Nigg (erich.nigg@unibas.ch) Cora-Ann Schoenenberger (cora-ann.schoenenberger@unibas.ch) |
| Content | This course will describe the structure and function of the eukaryotic nucleus. The nucleus serves as the "brain" of the cell. It contains the genetic information and ensures that it is properlly replicated, segregated, transcribed and repaired. Within the nucleus are functional compartments such as the nucleolus, whose function it is to produce ribosomes. The nucleus, which is membrane bound, has nuclear pores, which are complex, regulated machines that control the flow of material into and out of a nucleus. In this course, all features of the nucleus from regulated import/export through pores, to the compartmentalization of transcription, splicing, replication and repair will be covered. We will cover the pathology of nuclear defects, with a focus on mutations in structural components of the nucleus and how they compromise the integrity of the genome to cause tissue-‐specific disease. The structure and function of lamins and pore proteins in transcriptional control will be presented, as well as the structure and folding of chromosomes and their dynamics through the cell cycle. Subdiffusive movements of chromatin in interphase nuclei and the role of this dynamic behavior in repair and transcription will be discussed. The lectures will give an up-‐to-‐date overview of a complex structure-‐function problem that touches on crucial aspects of cell identity. |
| Comments | Unter Mitwirkung von: Vincent Dion, Helder Ferreira, Peter Meister, (alle FMI), Anna Santamaria (Biozentrum) Program: 18. September Chromosomal territories Thomas Cremer (LMU, Munich) 25. September Organization of the nucleus David Spector (CSHL) 2. October Nuclear organization and gene expression & repression Peter Meister (University of Bern) 9. October Nuclear lamins, pores and disease Martin Hetzer (Salk, La Jolla) or Roland Foisner (Vienna) 16. October Nucleus in cell differentiation – tissue specific compartments Susan Gasser (FMI, Basel) or Giacomo Cavalli (Montpellier) 23. October Nuclear pore complex and nucleocytoplasmic transport Michael Rout (Rockefeller U) 30. October Nuclear bodies Angus Lamond (Dundee) 6. November Types of chromatin and its distribution Bas van Steensel (NKI, Amsterdam) 13. November Chromosome structure and segregation Frank Uhlmann (CRUK, London) 20. November Actin and myosin in the nucleus C-A. Schoenenberger (Biozentrum, Basel) 27. November Diseases related to the nucleus Anna Mattout (FMI/Basel) 4. December Chromatin dynamics: techniques and interpretations Vincent Dion (FMI, Basel) 11. December DNA repair in the nucleus Dan Durocher (Toronto) or Michael Lisby (Denmark) 18. December Long range chromosome organization (HiC) Wouter de Laat () < Matthias Merkenschlager on condensin and cohesin in the nucleus |
| Weblink | http://www.biozentrum.unibas.ch/graduate |
| Language of instruction | English |
| Use of digital media | Online, optional |
| Interval | Weekday | Time | Room |
|---|
No dates available. Please contact the lecturer.
| Modules |
Cycle C: Growth & Development (PhD subject: Biochemistry) Cycle C: Growth & Development (PhD subject: Biophysics) Cycle C: Growth & Development (PhD subject: Genetics) Cycle C: Growth & Development (PhD subject: Microbiology) Cycle C: Growth & Development (PhD subject: Cell Biology) Cycle C: Growth & Development (PhD subject: Pharmacology) Cycle C: Growth & Development (PhD subject: Neurobiology) Cycle C: Growth & Development (PhD subject: Bioinformatics) Cycle C: Growth & Development (PhD subject: Structural Biology) Cycle C: Growth & Development (Master Molecular Biology) Module Specialisation: Molecular Biology (Master Nanosciences) |
| Assessment format | continuous assessment |
| Assessment registration/deregistration | Reg.: course registration; dereg.: teaching staff |
| Repeat examination | no repeat examination |
| Scale | Pass / Fail |
| Repeated registration | as often as necessary |
| Responsible faculty | Faculty of Science, studiendekanat-philnat@unibas.ch |
| Offered by | Departement Biozentrum |