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29957-01 - Lecture: Neurotoxicology (1 CP)
| Semester | spring semester 2014 |
| Course frequency | Every spring sem. |
| Lecturers |
Stefan Borgwardt (s.borgwardt@unibas.ch)
Anne Eckert (anne.eckert@unibas.ch) Matthias Emanuel Liechti (matthias.liechti@unibas.ch, Assessor) Nicole Schaeren-Wiemers (nicole.schaeren-wiemers@unibas.ch) |
| Content | Week 1: Introduction (M. Liechti), Nervous Tissue Par 1 (N. Schären-Wiemers) Week 2: Nervous Tissue Part 2 and Mechanisms of Neurodegeneration (N. Schären-Wiemers) Week 3: Mechanisms of Neurodegeneration Part 2 and Axonal Transport (N. Schären-Wiemers) Week 4: Cellular Assays (A. Eckert) and Cholinergic system (M. Liechti) Week 5: Monoamine, GABA and glutamargic systems (M. Liechti) Week 6: Neurological evaluation (M. Hardmeier); Neuroimaging (St. Borgwardt) Week 7: MC-Exam |
| Learning objectives | To understand the structural and function basics of the nervous system and how chemicals and drugs interact with neuronal structures and functions. Ability to evaluate example cases. |
| Bibliography | Lecture slides on ADAM. Klaassen, Casaretts & Dull’s, Toxicology, The basis science of poisons, Chapter: Toxic responses of the nervous system. Goodman & Gilman’s, Manual of Pharmacology and Therapeutics, paperback, McGraw Hill Medical, (available as small paper back or full hard cover book) a. Chapter 6-11: Drugs acting at synaptic and neuroeffector junctional sites b. Chapter 12-23: Drugs acting on the central nervous system and neurotransmission in the CNS Reading assignments (ADAM) Acute Toxicities of Organophosphates and Carbamates, Chapter 1 by JE Chambers and RL Carr; Handbook of Neurotoxicology Vol I by EJ Massaro, Humana Press, 2010 AND Neurotoxic effects of substitute amphetamines in rodents; Chapter 11 by JP O’Callaghan and DB Miller and Dopamine and Neuronal Damage. Handbook of Neurotoxicology Vol I by EJ Massaro, Humana Press, 2010 |
| Admission requirements | Bachelor's degree |
| Language of instruction | English |
| Use of digital media | No specific media used |
| Interval | Weekday | Time | Room |
|---|
No dates available. Please contact the lecturer.
| Modules |
Module Specialisation: Toxicology (Master Pharmaceutical Sciences) Module Specific Knowledge in Toxicology (Master Toxicology) (Pflicht) |
| Assessment format | continuous assessment |
| Assessment details | Please refert to the list: http://pharma.unibas.ch/teaching/leistungsueberpruefungen/lluep/ |
| Assessment registration/deregistration | Reg.: course registration; dereg.: teaching staff |
| Repeat examination | no repeat examination |
| Scale | 1-6 0,5 |
| Repeated registration | as often as necessary |
| Responsible faculty | Faculty of Science, studiendekanat-philnat@unibas.ch |
| Offered by | Departement Pharmazeutische Wissenschaften |