Back to selection
13186-01 - Lecture: Frontiers in RNA Biology (2 CP)
| Semester | fall semester 2014 |
| Course frequency | Every 2nd fall sem. |
| Lecturers |
Marc Bühler (marc.buehler@unibas.ch, Assessor)
Rafal Ciosk (rafal.ciosk@unibas.ch) Helge Grosshans (helge.grosshans@unibas.ch) |
| Content | Content:This course will cover a broad spectrum of RNA related topics. Local and outside lecturers who are leaders in their respective fields will teach the course. Each topic will be introduced by 45-minute general lecture followed by a more specific, traditional research seminar highlighting the latest results of the lecturers laboratory. 25.09. RNA: molecule for all seasons Witek Filipowicz / 02.10. no lecture / 09.10. RNA quality control/decay Georg Stöcklin / 16.10. mRNA translation Rafal Ciosk / 23.10. RNA localization Jeff Chao / 30.10. Structure of RNA-protein interactions Fred Allain / 06.11. miRNAs and RNAi Helge Grosshans Room 5.39 / 13.11. mRNA processing Herve le Hir / 20.11. RNA-based defense mechanisms in prokaryotes Martin Jinek / 27.11. Small RNAs in eukaryotic genome regulation Marc Bühler / 04.12. RNA-omics Jernei Ule / 11.12. small RNA biology and PTGS in plants Fred Meins / 18.12. RNA therapeutics Jonathan Hall |
| Bibliography | The discovery that RNA is not only a carrier of genetic information or a structural scaffold in ribonucleoprotein particles but can also act as a catalyst in many different cellular processes, greatly stimulated research on the structure, processing and function of RNA. The lecture will cover the following topics: chemistry and structure of RNA; major classes of cellular RNAs (mRNAs, tRNAs, rRNAs, snRNAs, and the newly discovered small regulatory ~20-nt RNAs); chemistry and structure of RNA; pre-mRNA processing with emphasis on splicing and polyadenylation; biogenesis of tRNA and rRNA; biochemistry and function of RNA interference (RNAi) and microRNAs; RNA trafficking in the cell, RNA quality control and RNA degradation; and regulated mRNA translation during development. Also covered are RNA-protein interactions and major classes of ribonucleoprotein particles and the evolution of RNAs. 25.09. RNA: molecule for all seasons Witek Filipowicz 02.10. no lecture 09.10. RNA quality control/decay Georg Stöcklin 16.10. mRNA translation Rafal Ciosk 23.10. RNA localization Jeff Chao 30.10. Structure of RNA-protein interactions Fred Allain 06.11. miRNAs and RNAi Helge Grosshans 13.11. mRNA processing Herve le Hir 20.11. RNA-based defense mechanisms in prokaryotes Martin Jinek 27.11. Small RNAs in eukaryotic genome regulation Marc Bühler 04.12. RNA-omics Jernei Ule 11.12. small RNA biology and PTGS in plants Fred Meins 18.12. RNA therapeutics Jonathan Hall |
| Comments | http://www.biozentrum.unibas.ch/education/phd/graduate-program/cycle-g/ With Jeffrey Chao and invited lecturers. |
| Weblink | https://adam.unibas.ch |
| Language of instruction | English |
| Use of digital media | Online, optional |
| Interval | Weekday | Time | Room |
|---|
No dates available. Please contact the lecturer.
| Modules |
Cycle G: Gene Expression and Epigenetics (PhD subject: Biochemistry) Cycle G: Gene Expression and Epigenetics (PhD subject: Biophysics) Cycle G: Gene Expression and Epigenetics (PhD subject: Genetics) Cycle G: Gene Expression and Epigenetics (PhD subject: Microbiology) Cycle G: Gene Expression and Epigenetics (PhD subject: Cell Biology) Cycle G: Gene Expression and Epigenetics (PhD subject: Pharmacology) Cycle G: Gene Expression and Epigenetics (PhD subject: Neurobiology) Cycle G: Gene Expression and Epigenetics (PhD subject: Bioinformatics) Cycle G: Gene Expression and Epigenetics (PhD subject: Structural Biology) Cycle G: Gene Expression and Epigenetics (Master Molecular Biology) Module Specialisation: Molecular Biology (Master Nanosciences) |
| Assessment format | continuous assessment |
| Assessment registration/deregistration | Reg.: course registration; dereg.: teaching staff |
| Repeat examination | no repeat examination |
| Scale | Pass / Fail |
| Repeated registration | as often as necessary |
| Responsible faculty | Faculty of Science, studiendekanat-philnat@unibas.ch |
| Offered by | Departement Biozentrum |