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27247-01 - Lecture: Computational Biology II: Sequence Modeling and Analysis (4 CP)
| Semester | spring semester 2019 |
| Further events belonging to these CP |
27247-01 (Lecture) 27247-02 (Practical course) |
| Course frequency | Every spring sem. |
| Lecturers | Mihaela Zavolan (mihaela.zavolan@unibas.ch, Assessor) |
| Content | The course introduces fundamental concepts and algorithms in bioinformatics. More specifically, it covers the following topics: • Evolution: definitions, mathematical models describing evolution of large and small populations. • Phylogeny: reconstructing the evolutionary relationships between species based on their genomic sequences. • Sequence alignments: the pairwise and multiple sequence alignment problems. • Functional annotation: Finding genes and regulatory sequences in the genome. • Describing relationships between protein sequences: Hidden Markov models of protein domains • Functional RNAs: RNA secondary structure and annotation of functional RNAs • Gene expression analysis: Inferring the relative abundance of RNA molecules from RNA sequencing data |
| Learning objectives | Students learn about the basic problem domain of bioinformatics as well as a wide range of algorithms for sequence analysis. They will learn about the commonly used languages of bioinformatics (mostly Python) and will implement basic bioinformatics algorithms. |
| Weblink | https://adam.unibas.ch |
| Admission requirements | First year courses must be accomplished. Mathematical background is needed in calculus, linear algrebra, diffential equations. Knowledge about discrete mathematics, stochastic processes and fundamental computer science algorithms is a plus. Basic programming skills and basic understanding in physics, chemistry and molecular biology (cells, DNA, RNA, proteins, etc.) is necessary. |
| Language of instruction | English |
| Use of digital media | No specific media used |
| Interval | Weekday | Time | Room |
|---|
No dates available. Please contact the lecturer.
| Modules |
Cycle E: Computational and Systems Biology (Master's Studies: Molecular Biology) Module Specialisation: Computational Intelligence (Bachelor's Studies: Computer Science (Start of studies before 01.08.2016)) Module Specialisation: Computer Science of Life Science (Bachelor's Studies: Computer Science (Start of studies before 01.08.2016)) Module: Applications and Related Topics (Bachelor's Studies: Computer Science) Module: Computational Biology (Bachelor's Studies: Computational Sciences) (Pflicht) Module: Computational Chemistry (Bachelor's Studies: Computational Sciences) Module: Computational Physics (Bachelor's Studies: Computational Sciences) Module: Computational Sciences II (Bachelor's Studies: Computational Sciences) Vertiefungsmodul: Bioinformatik (Bachelor's Studies: Computer Science (Start of studies before 01.08.2010)) (Pflicht) Vertiefungsmodul: Computer Science (Bachelor's Studies: Computer Science (Start of studies before 01.08.2010)) |
| Assessment format | continuous assessment |
| Assessment details | Written exam and exercises Exam: Monday, 27.5.2019, 13:00–14:00h; Lounge, Klingelbergstrasse 61, room 1301, floor E13 |
| Assessment registration/deregistration | Reg.: course registration, dereg: cancel course registration |
| Repeat examination | no repeat examination |
| Scale | 1-6 0,5 |
| Repeated registration | as often as necessary |
| Responsible faculty | Faculty of Science, studiendekanat-philnat@unibas.ch |
| Offered by | Departement Biozentrum |