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10415-01 - Main lecture: Structural Biology (2 CP)
| Semester | spring semester 2025 |
| Course frequency | Every spring sem. |
| Lecturers | Timm Maier (timm.maier@unibas.ch, Assessor) |
| Content | Programm: 1. Introduction: anatomy of a protein, structure determination methods, molecular graphics 2. From polypeptide to structure: interactions, folds, homology 3. Structure/function relationships: proteases, kinase, phosphotases 4. Conformational changes: allosteric control, molecular symmetry, signal transduction 5. Filaments and aggregates: cytoskeleton, prions, amyloids 6. Molecular motors 7. Membranes and membrane proteins: transporters and channels, receptors 8. DNA structure and replication, RNA biosynthesis and nucleocytoplasmic transport 9. The ribosome, protein biosynthesis, chaperones, quality control & degradation 10. Bioenergetics: Mitochondrian ATP synthesis and Photosynthesis 11. Biosynthetic networks and complexes, multienzymes and assembly lines 12. Metabolic regulation: Sensors, signalling modules and cascades and the TOR complexes 13. Questions & Answers, test exam in subgroups |
| Learning objectives | Folgende Fragen sollten am Ende des Kurses u.a. beantwortet werden können: Welche molekularen Wechselwirkungen bewirken Strukturbildung, welche wiederkehrenden Strukturmuster gibt es, inwieweit ist strukturelle Flexibilität wichtig, wie werden biologische Strukturen bestimmt, wozu werden strukturelle Erkenntnisse eingesetzt, wie können Strukturen vorhergesagt werden? Des weiteren werden die Studierenden mit ausgewählten Beispielen zu Struktur-Funktionsbeziehungen vertraut gemacht. |
| Bibliography | Vortragsmaterialien werden elektronisch zur Verfügung gestellt. Generelle Biochemie- und Zellbiologie-Lehrbücher können zur Vor- und Nachbearbeitung herangezogen werden: - Textbook Of Structural Biology, Anders Liljas, Lars Liljas, Jure Piskur, Göran Lindblom, Poul Nissen, Morten Kjeldgaard (ISBN 978-9812772084) - Lehninger Principles of Biochemistry, 7th Edition, David L. Nelson, Michael M. Cox (ISBN 978-1319108243) - Fundamentals of Biochemistry: Life at the Molecular Level, 5th Edition, Donald Voet, Judith G. Voet, Charlotte W. Pratt (ISBN 978-1-118-91846-3) Detaillierte Angaben, auch zu Originalliteratur, erfolgen in den Vorlesungen. Elektronische Feedback-Möglichkeit via Mobilgerät auf www.movo.ch |
| Weblink | https://adam.unibas.ch |
| Language of instruction | English |
| Use of digital media | No specific media used |
| Course auditors welcome |
| Interval | Weekday | Time | Room |
|---|---|---|---|
| wöchentlich | Tuesday | 10.15-12.00 | Biozentrum, Hörsaal U1.131 |
| unregelmässig | See individual dates | ||
Dates
| Date | Time | Room |
|---|---|---|
| Tuesday 18.02.2025 | 10.15-12.00 | Biozentrum, Hörsaal U1.131 |
| Tuesday 25.02.2025 | 10.15-12.00 | Biozentrum, Hörsaal U1.131 |
| Tuesday 25.02.2025 | 12.15-14.00 | Biozentrum, Seminarraum U1.193 |
| Tuesday 04.03.2025 | 10.15-12.00 | Biozentrum, Hörsaal U1.131 |
| Tuesday 04.03.2025 | 12.15-14.00 | Biozentrum, Seminarraum U1.193 |
| Tuesday 11.03.2025 | 10.15-12.00 | Fasnachstferien |
| Tuesday 11.03.2025 | 12.15-14.00 | Fasnachstferien |
| Tuesday 18.03.2025 | 10.15-12.00 | Biozentrum, Hörsaal U1.131 |
| Tuesday 18.03.2025 | 12.15-14.00 | Biozentrum, Seminarraum U1.193 |
| Tuesday 25.03.2025 | 10.15-12.00 | Biozentrum, Hörsaal U1.131 |
| Tuesday 01.04.2025 | 10.15-12.00 | Biozentrum, Hörsaal U1.131 |
| Tuesday 08.04.2025 | 10.15-12.00 | Biozentrum, Hörsaal U1.131 |
| Tuesday 15.04.2025 | 10.15-12.00 | Biozentrum, Hörsaal U1.131 |
| Tuesday 22.04.2025 | 10.15-12.00 | Biozentrum, Hörsaal U1.131 |
| Tuesday 29.04.2025 | 10.15-12.00 | Biozentrum, Hörsaal U1.131 |
| Tuesday 06.05.2025 | 10.15-12.00 | Biozentrum, Hörsaal U1.131 |
| Tuesday 13.05.2025 | 10.15-12.00 | Biozentrum, Hörsaal U1.131 |
| Tuesday 20.05.2025 | 10.15-12.00 | Biozentrum, Hörsaal U1.131 |
| Tuesday 27.05.2025 | 10.15-12.00 | Biozentrum, Hörsaal U1.131 |
| Modules |
Modul: Computational Biology (Bachelor's Studies: Computational Sciences) Modul: Computational Biology (Bachelor's Studies: Computational Sciences) Modul: Computational Biology (Bachelor's Studies: Computational Sciences) Modul: Computational Biology (Bachelor's Studies: Computational Sciences) Modul: Computational Biology (Bachelor's Studies: Computational Sciences) Modul: Naturwissenschaften (Bachelor's Studies: Computational Sciences) Modul: Naturwissenschaften (Bachelor's Studies: Computational Sciences) Modul: Naturwissenschaften (Bachelor's Studies: Computational Sciences) Modul: Naturwissenschaften (Bachelor's Studies: Computational Sciences) Module: Biology 4 (Bachelor's Studies: Biology (Start of studies before 01.08.2022)) Module: Biology 4 (Bachelor's Studies: Biology) Module: Biology 4 (Bachelor's degree subject: Biology) Module: Computational Biology (Bachelor's Studies: Computational Sciences (Start of studies before 01.08.2023)) Module: Molecular Biology (Bachelor's Studies: Nanosciences) Module: Natural Sciences (Bachelor's Studies: Computational Sciences (Start of studies before 01.08.2023)) |
| Assessment format | exam |
| Assessment details | Written exam after the 4th semester, 45 Min. All informations about the exam, like registration, duration, date and type of the exam, will be announced on https://philnat.unibas.ch/de/examen (For provisional dates see https://bio.unibas.ch/en/examinations/main-lecture-exams/) |
| Assessment registration/deregistration | Reg.: in 'course reg.'; dereg.: Dean of Std. Off. in writing |
| Repeat examination | one repetition, best attempt counts |
| Scale | 1-6 0,5 |
| Repeated registration | no repetition |
| Responsible faculty | Faculty of Science, studiendekanat-philnat@unibas.ch |
| Offered by | Departement Biozentrum |