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44812-01 - Vorlesung: Mechanisms of Toxicity (1 KP)
| Semester | Herbstsemester 2025 |
| Course frequency | Jedes Herbstsemester |
| Lecturers |
Christian Appenzeller-Herzog (christian.appenzeller@unibas.ch)
Jamal Bouitbir (jamal.bouitbir@unibas.ch, Assessor) Alex Odermatt (alex.odermatt@unibas.ch) |
| Content | The following mechanisms will be discussed: general principles of interaction with cells and proteins, repair mechanisms, mitochondrial respiratory chain, uncoupling, mitochondrial DNA, mitochondrial fatty acid oxidation. ER stress response, redox reactions, lysosomes, phospholipidosis, cytokines, inflammasome, apoptosis, necrosis, nuclear receptors, and ion homeostasis. |
| Learning objectives | At the end of this series of lectures, students should understand the general principles of toxicological mechanisms and should understand how toxicants can damage cellular organelles and cells. |
| Bibliography | Klaassen CD, Casarett and Doull's Essentials of Toxicology. McGraw-Hill. Newest edition. Klaassen CD. Casarett and Doull's Toxicology, the basic Science of Poisons. McGraw-Hill. Newest edition. |
| Comments | Film and sound recordings during the course are strictly forbidden (recorders may be confiscated). |
| Weblink | Department of Pharmaceutical Sciences |
| Admission requirements | Completed Bachelor degree. |
| Language of instruction | Englisch |
| Use of digital media | kein spezifischer Einsatz |
| Interval | Weekday | Time | Room |
|---|---|---|---|
| wöchentlich | Tuesday | 13.15-15.00 | Pharmazentrum, Hörsaal 2 |
Dates
| Date | Time | Room |
|---|---|---|
| Tuesday 16.09.2025 | 13.15-15.00 | Pharmazentrum, Hörsaal 2 |
| Tuesday 23.09.2025 | 13.15-15.00 | Pharmazentrum, Hörsaal 2 |
| Tuesday 30.09.2025 | 13.15-15.00 | Pharmazentrum, Hörsaal 2 |
| Tuesday 07.10.2025 | 13.15-15.00 | Pharmazentrum, Hörsaal 2 |
| Tuesday 14.10.2025 | 13.15-15.00 | Pharmazentrum, Hörsaal 2 |
| Tuesday 21.10.2025 | 13.15-15.00 | Pharmazentrum, Hörsaal 2 |
| Tuesday 28.10.2025 | 13.45-14.45 | Biozentrum, Hörsaal U1.101 |
| Modules |
Modul: Translating Pharmacology and Drug Safety to Humans (Masterstudium: Drug Sciences) Wahlbereich Master Pharmazie: Empfehlungen (Masterstudium: Pharmazie) |
| Assessment format | Lehrveranst.-begleitend |
| Assessment details | Refer to this link:https://pharma.unibas.ch/en/education/assessments-and-credit-points/continuous-assessments/ |
| Assessment registration/deregistration | Anm.: Belegen Lehrveranstaltung; Abm.: stornieren |
| Repeat examination | keine Wiederholungsprüfung |
| Scale | 1-6 0,5 |
| Repeated registration | beliebig wiederholbar |
| Responsible faculty | Philosophisch-Naturwissenschaftliche Fakultät, studiendekanat-philnat@unibas.ch |
| Offered by | Departement Pharmazeutische Wissenschaften |