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13186-01 - Lecture: Frontiers in RNA Biology (2 CP)
| Semester | fall semester 2025 |
| Course frequency | Every 2nd fall sem. |
| Lecturers |
Marc Bühler (marc.buehler@unibas.ch, Assessor)
Jeffrey Chao (jeffrey.chao@unibas.ch) Helge Grosshans (helge.grosshans@unibas.ch) |
| Content | The discovery that RNA is not only a carrier of genetic information or a structural scaffold in ribonucleoprotein particles but can also act as a catalyst in many different cellular processes, greatly stimulated research on the structure, processing and function of RNA. The lecture will cover the following topics: chemistry and structure of RNA; major classes of cellular RNAs (mRNAs, tRNAs, rRNAs, snRNAs, and the newly discovered small regulatory ~20-nt RNAs); chemistry and structure of RNA; pre-mRNA processing with emphasis on splicing and polyadenylation; biogenesis of tRNA and rRNA; biochemistry and function of RNA interference (RNAi) and microRNAs; RNA trafficking in the cell, RNA quality control and RNA degradation; and regulated mRNA translation during development. Also covered are RNA-protein interactions and major classes of ribonucleoprotein particles and the evolution of RNAs. |
| Comments | Thursdays 10:00 - 12:00 @FMI Institute, Room 0.60/61 Invited speakers |
| Weblink | Graduate Teaching Program |
| Language of instruction | English |
| Use of digital media | Online, optional |
| Interval | Weekday | Time | Room |
|---|---|---|---|
| wöchentlich | Thursday | 10.00-12.00 | - Siehe Bemerkung |
Dates
| Modules |
Cycle G: Gene Expression and Epigenetics (Master's Studies: Molecular Biology (Start of studies before 01.08.2025)) Doctorate Biochemistry: Recommendations (PhD subject: Biochemistry) Doctorate Biophysics: Recommendations (PhD subject: Biophysics) Doctorate Cell Biology: Recommendations (PhD subject: Cell Biology) Doctorate Computational Biology: Recommendations (PhD subject: Computational Biology) Doctorate Genetics: Recommendations (PhD subject: Genetics) Doctorate Microbiology: Recommendations (PhD subject: Microbiology) Doctorate Molecular Biology: Recommendations (PhD subject: Molecular Biology) Doctorate Neurobiology: Recommendations (PhD subject: Neurobiology) Doctorate Pharmacology: Recommendations (PhD subject: Pharmacology) Doctorate Structural Biology: Recommendations (PhD subject: Structural Biology) Module Specialisation: Molecular Biology (Master's Studies: Nanosciences) Module: Cycle G: Gene Expression and Epigenetics (Master's Studies: Molecular Biology) |
| Assessment format | continuous assessment |
| Assessment registration/deregistration | Reg.: course registration, dereg: cancel course registration |
| Repeat examination | no repeat examination |
| Scale | Pass / Fail |
| Repeated registration | as often as necessary |
| Responsible faculty | Faculty of Science, studiendekanat-philnat@unibas.ch |
| Offered by | Departement Biozentrum |