Back to selection
29955-01 - Lecture: Immunosafety (1 CP)
| Semester | spring semester 2026 |
| Course frequency | Every spring sem. |
| Lecturers |
José Manuel Carballido Herrera (jose.carballido@unibas.ch)
Alex Odermatt (alex.odermatt@unibas.ch, Assessor) Daniel Yerly (daniel.yerly@unibas.ch) |
| Content | Principles of immunosafety; Immunotoxicology of drugs. Innate and adaptive immunity; Relevance of immune responses for drug immunosafety. Regulatory aspects and immunosafety requirements by clinical phases. Immunosafety risk assessment; Immunosafety toolbox. Hypersensitivity and adverse reactions to low molecular weight compounds; Mechanisms: haptens, pharmacologic interactions, altered peptide repertoires; Clinical manifestations: anaphylaxis, DRESS, serum sickness, contact dermatitis; Genetic predispositions: HLA alleles, drug-related triggers; Clinical diagnosis: Patient history, symptom timing, severity scales; Testing methods: Skin prick, intradermal, patch tests; IgE tests, basophil activation assays; LTT, cytokine release tests. New therapeutic modalities; Protein biologics: antibodies, antibody mimetics, enzymes and growth factors; RNA therapeutics: aptamers, antisense oligonucleotides, siRNA, mRNA, CRISPR-based genome editing; Cell and gene therapies: adeno-associated viral vectors, chimeric antigen receptors; Radioligands. Risk mitigation strategies: immune stimulatory effects of drugs, immune suppressive effects of drugs; Balancing effects of immunomodulators. Developing strategies to block immunogenicity: targeted delivery systems, immune tolerance. Real world workshop: case presentations, analysis and discussions |
| Learning objectives | Ascertain the basic principles of immunology and immune reactivity to drugs. Learn the principles of immunotoxicological hazard and risk assessment of drugs. Understand drug-induced hypersensitivity and immunogenicity to established and new therapeutic modalities. Familiarize with mitigation strategies to prevent and treat immunogenicity reactions. Get insights into real-world immunogenicity situations. |
| Bibliography | Peter J. Delves, Seamus J. Martin, Dennis R. Burton, Ivan M. Roitt: Roitt's Essential Immunology; 13th Edition; Wiley-Blackwell; 2017 |
| Comments | Film and sound recordings during the course are strictly forbidden (recorders may be confiscated) |
| Weblink | Department of Pharmaceutical Sciences |
| Admission requirements | Completed Bachelor degree |
| Language of instruction | English |
| Use of digital media | No specific media used |
| Interval | Weekday | Time | Room |
|---|---|---|---|
| wöchentlich | Tuesday | 13.15-15.00 | Pharmazentrum, Hörsaal 2 |
Dates
| Date | Time | Room |
|---|---|---|
| Tuesday 17.02.2026 | 13.15-15.00 | Pharmazentrum, Hörsaal 2 |
| Tuesday 24.02.2026 | 13.15-15.00 | Fasnachtswoche |
| Tuesday 03.03.2026 | 13.15-15.00 | Pharmazentrum, Hörsaal 2 |
| Tuesday 10.03.2026 | 13.15-15.00 | Pharmazentrum, Hörsaal 2 |
| Tuesday 17.03.2026 | 13.15-15.00 | Pharmazentrum, Hörsaal 2 |
| Tuesday 24.03.2026 | 13.15-15.00 | Pharmazentrum, Hörsaal 2 |
| Tuesday 31.03.2026 | 13.15-15.00 | Pharmazentrum, Hörsaal 2 |
| Monday 20.04.2026 | 08.45-09.45 | Pharmazentrum, Hörsaal 1 |
| Modules |
Electives Master Science in Pharmacy: Recommendations (Master's Studies: Pharmacy) Module Specialisation: Medical Nanosciences (Master's Studies: Nanosciences) Module: Translating Pharmacology and Drug Safety to Humans (Master's Studies: Drug Sciences) |
| Assessment format | continuous assessment |
| Assessment details | Please refer to the list: https://pharma.unibas.ch/en/education/assessments-and-credit-points/continuous-assessments/ |
| Assessment registration/deregistration | Reg.: course registration, dereg: cancel course registration |
| Repeat examination | no repeat examination |
| Scale | 1-6 0,5 |
| Repeated registration | as often as necessary |
| Responsible faculty | Faculty of Science, studiendekanat-philnat@unibas.ch |
| Offered by | Departement Pharmazeutische Wissenschaften |