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13709-01 - Lecture: Transcription Regulation and Gene expression in Eukaryotes (2 CP)
| Semester | spring semester 2026 |
| Course frequency | Every 2nd spring sem |
| Lecturers |
Jeffrey Chao (jeffrey.chao@unibas.ch)
Luca Giorgetti (luca.giorgetti@unibas.ch) Patrick D. Matthias (patrick.matthias@unibas.ch, Assessor) |
| Content | This course deals with transcriptional regulation and gene expression, in particular in eukaryotes. The emphasis will be put on understanding the regulatory interplay between transcription factors and their crucial role in translating environmental and developmental cues into coordinated activation of the genome. Topics that will be discussed include: Regulatory DNA sequences: promoters, enhancers, locus control regions; General transcription machinery; Transcription factors, cell-specific and ubiquitous; Mechanistic aspects of transcription activation; Chromatin, histone modifications, DNA methylation; Genome 3D organization and its impact on gene expression; Gene regulatory networks; Enhancers and Super-enhancers as integrators of gene activity; Transcription factors as master controlers of cellular differentiation; Transcription factors in health and disease; Functional dissection of transcription control by genome-wide screens; Quantitative analysis of transcription control. |
| Comments | Please contact Patrick Matthias exclusively: patrick.matthias@fmi.ch other lecturers: Jörg Betschinger |
| Weblink | Graduate Teaching Program |
| Language of instruction | English |
| Use of digital media | Online, optional |
| Interval | Weekday | Time | Room |
|---|---|---|---|
| wöchentlich | Wednesday | 16.15-18.00 | Biozentrum, Seminarraum U1.191 |
Dates
| Date | Time | Room |
|---|---|---|
| Wednesday 18.02.2026 | 16.15-18.00 | Biozentrum, Seminarraum U1.191 |
| Wednesday 25.02.2026 | 16.15-18.00 | Fasnachtsferien |
| Wednesday 04.03.2026 | 16.15-18.00 | Biozentrum, Seminarraum U1.191 |
| Wednesday 11.03.2026 | 16.15-18.00 | Biozentrum, Seminarraum U1.191 |
| Wednesday 18.03.2026 | 16.15-18.00 | Biozentrum, Seminarraum U1.191 |
| Wednesday 25.03.2026 | 16.15-18.00 | Biozentrum, Seminarraum U1.191 |
| Wednesday 01.04.2026 | 16.15-18.00 | Biozentrum, Seminarraum U1.191 |
| Wednesday 08.04.2026 | 16.15-18.00 | Biozentrum, Seminarraum U1.191 |
| Wednesday 15.04.2026 | 16.15-18.00 | Biozentrum, Seminarraum 02.073 |
| Wednesday 22.04.2026 | 16.15-18.00 | Biozentrum, Seminarraum U1.191 |
| Wednesday 29.04.2026 | 16.15-18.00 | Biozentrum, Seminarraum U1.191 |
| Wednesday 06.05.2026 | 16.15-18.00 | Biozentrum, Seminarraum U1.191 |
| Wednesday 13.05.2026 | 16.15-18.00 | Biozentrum, Seminarraum U1.191 |
| Wednesday 20.05.2026 | 16.15-18.00 | Biozentrum, Seminarraum U1.191 |
| Wednesday 27.05.2026 | 16.15-18.00 | Biozentrum, Seminarraum U1.191 |
| Modules |
Cycle G: Gene Expression and Epigenetics (Master's Studies: Molecular Biology (Start of studies before 01.08.2025)) Doctorate Biochemistry: Recommendations (PhD subject: Biochemistry) Doctorate Biophysics: Recommendations (PhD subject: Biophysics) Doctorate Cell Biology: Recommendations (PhD subject: Cell Biology) Doctorate Computational Biology: Recommendations (PhD subject: Computational Biology) Doctorate Genetics: Recommendations (PhD subject: Genetics) Doctorate Microbiology: Recommendations (PhD subject: Microbiology) Doctorate Molecular Biology: Recommendations (PhD subject: Molecular Biology) Doctorate Neurobiology: Recommendations (PhD subject: Neurobiology) Doctorate Pharmacology: Recommendations (PhD subject: Pharmacology) Doctorate Structural Biology: Recommendations (PhD subject: Structural Biology) Module Specialisation: Molecular Biology (Master's Studies: Nanosciences) Module: Cycle G: Gene Expression and Epigenetics (Master's Studies: Molecular Biology) Vertiefungsfächer Theorie und Vertiefungsfächer Biologie (Master's Studies: Computational Biology and Bioinformatics) |
| Assessment format | continuous assessment |
| Assessment registration/deregistration | Reg.: course registration, dereg: cancel course registration |
| Repeat examination | no repeat examination |
| Scale | Pass / Fail |
| Repeated registration | as often as necessary |
| Responsible faculty | Faculty of Science, studiendekanat-philnat@unibas.ch |
| Offered by | Departement Biozentrum |