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27247-01 - Lecture: Computational Biology II: Sequence Modeling and Analysis (4 CP)
| Semester | spring semester 2026 |
| Course frequency | Every spring sem. |
| Lecturers | Mihaela Zavolan (mihaela.zavolan@unibas.ch, Assessor) |
| Content | This course will introduce students to fundamental problems in Bioinformatics/Computational Biology such as: - Evolution: Mathematical models for the evolution of DNA sequences. - Alignment and Phylogeny reconstruction: inferring evolutionary relationships between sequences. - Functional annotation: Finding genes and regulatory sequences in fully sequenced genomes. - Families of coding sequences: Hidden Markov models of protein domains - Gene expression networks: Inferring regulatory factors driving gene expression. Students should have a good understanding of calculus, linear algebra, combinatorics and algorithms and should be familiar with concepts of molecular biology. |
| Learning objectives | Students learn about the basic problem domain of bioinformatics as well as a wide range of algorithms for sequence analysis. They will learn about the commonly used languages of bioinformatics (mostly Python) and will implement basic bioinformatics algorithms. |
| Weblink | https://adam.unibas.ch |
| Admission requirements | First year courses must be accomplished. Mathematical background is needed in calculus, linear algrebra, diffential equations. Knowledge about discrete mathematics, stochastic processes and fundamental computer science algorithms is a plus. Basic programming skills and basic understanding in physics, chemistry and molecular biology (cells, DNA, RNA, proteins, etc.) is necessary. |
| Language of instruction | English |
| Use of digital media | No specific media used |
| Interval | Weekday | Time | Room |
|---|---|---|---|
| wöchentlich | Thursday | 11.15-13.00 | Biozentrum, Seminarraum 02.094 |
Dates
| Date | Time | Room |
|---|---|---|
| Thursday 19.02.2026 | 11.15-13.00 | Biozentrum, Seminarraum 02.094 |
| Thursday 26.02.2026 | 11.15-13.00 | Fasnachtsferien |
| Thursday 05.03.2026 | 11.15-13.00 | Biozentrum, Seminarraum 02.094 |
| Thursday 12.03.2026 | 11.15-13.00 | Biozentrum, Seminarraum 02.094 |
| Thursday 19.03.2026 | 11.15-13.00 | Biozentrum, Seminarraum 02.094 |
| Thursday 26.03.2026 | 11.15-13.00 | Biozentrum, Seminarraum 02.094 |
| Thursday 02.04.2026 | 11.15-13.00 | Ostern |
| Thursday 09.04.2026 | 11.15-13.00 | Biozentrum, Seminarraum 02.094 |
| Thursday 16.04.2026 | 11.15-13.00 | Biozentrum, Seminarraum 02.094 |
| Thursday 23.04.2026 | 11.15-13.00 | Biozentrum, Seminarraum 02.094 |
| Thursday 30.04.2026 | 11.15-13.00 | Biozentrum, Seminarraum 02.094 |
| Thursday 07.05.2026 | 11.15-13.00 | Biozentrum, Seminarraum 02.094 |
| Thursday 14.05.2026 | 11.15-13.00 | Auffahrt |
| Thursday 21.05.2026 | 11.15-13.00 | Biozentrum, Seminarraum 02.094 |
| Thursday 28.05.2026 | 11.15-13.00 | Biozentrum, Seminarraum 02.094 |
| Modules |
Cycle E: Computational and Systems Biology (Master's Studies: Molecular Biology (Start of studies before 01.08.2025)) Modul: Computational Biology (Bachelor's Studies: Computational Sciences) Modul: Computational Biology (Bachelor's Studies: Computational Sciences) Modul: Computational Biology (Bachelor's Studies: Computational Sciences) Modul: Computational Biology (Bachelor's Studies: Computational Sciences) Modul: Computational Methods (Bachelor's Studies: Computational Sciences) Modul: Computational Methods (Bachelor's Studies: Computational Sciences) Modul: Computational Methods (Bachelor's Studies: Computational Sciences) Modul: Computational Methods (Bachelor's Studies: Computational Sciences) Module: Applications and Related Topics (Bachelor's Studies: Computer Science) Module: Computational Biology (Bachelor's Studies: Computational Sciences (Start of studies before 01.08.2023)) Module: Computational Sciences II (Bachelor's Studies: Computational Sciences (Start of studies before 01.08.2023)) Module: Cycle E: Computational and Systems Biology (Master's Studies: Molecular Biology) |
| Assessment format | continuous assessment |
| Assessment details | Exam: 22.05.2025, 11:15-13:00h, Ort folgt |
| Assessment registration/deregistration | Reg.: course registration, dereg: cancel course registration |
| Repeat examination | no repeat examination |
| Scale | 1-6 0,5 |
| Repeated registration | as often as necessary |
| Responsible faculty | Faculty of Science, studiendekanat-philnat@unibas.ch |
| Offered by | Departement Biozentrum |