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19520-01 - Lecture: Gene Expression in Eukaryotes (2 CP)
| Semester | fall semester 2026 |
| Course frequency | Irregular |
| Lecturers |
Jeffrey Chao (jeffrey.chao@unibas.ch, Assessor)
Luca Giorgetti (luca.giorgetti@unibas.ch) Alexander Schmidt (alex.schmidt@unibas.ch) |
| Content | In this lecture, we will be covering gene expression in Eukaryotes beginning with transcription in the nucleus and ending with degradation of proteins in the cytoplasm. Topics that will be discussed include Regulatory DNA sequences: promoters, enhancers, locus control regions; General transcription machinery; Transcription factors, cell-specific and ubiquitous; Mechanistic aspects of transcription activation; Chromatin, histone modifications, DNA methylation; Genome 3D organization and its impact on gene expression; Gene regulatory networks; Enhancers and Super-enhancers as integrators of gene activity; Transcription factors as master controlers of cellular differentiation; Transcription factors in health and disease; Functional dissection of transcription control by genome-wide screens; Quantitative analysis of transcription control; mRNA stability; translation regulation; RNA localization; protein modification and protein degradation |
| Weblink | Graduate Teaching Program |
| Language of instruction | English |
| Use of digital media | No specific media used |
| Interval | Weekday | Time | Room |
|---|
No dates available. Please contact the lecturer.
| Modules |
Cycle G: Gene Expression and Epigenetics (Master's Studies: Molecular Biology (Start of studies before 01.08.2025)) Doctorate Biochemistry: Recommendations (PhD subject: Biochemistry) Doctorate Biophysics: Recommendations (PhD subject: Biophysics) Doctorate Cell Biology: Recommendations (PhD subject: Cell Biology) Doctorate Computational Biology: Recommendations (PhD subject: Computational Biology) Doctorate Genetics: Recommendations (PhD subject: Genetics) Doctorate Microbiology: Recommendations (PhD subject: Microbiology) Doctorate Molecular Biology: Recommendations (PhD subject: Molecular Biology) Doctorate Neurobiology: Recommendations (PhD subject: Neurobiology) Doctorate Pharmacology: Recommendations (PhD subject: Pharmacology) Doctorate Structural Biology: Recommendations (PhD subject: Structural Biology) Module Specialisation: Molecular Biology (Master's Studies: Nanosciences) Module: Cycle G: Gene Expression and Epigenetics (Master's Studies: Molecular Biology) Vertiefungsfächer Theorie und Vertiefungsfächer Biologie (Master's Studies: Computational Biology and Bioinformatics) |
| Assessment format | continuous assessment |
| Assessment registration/deregistration | Reg.: course registration, dereg: cancel course registration |
| Repeat examination | no repeat examination |
| Scale | Pass / Fail |
| Repeated registration | as often as necessary |
| Responsible faculty | Faculty of Science, studiendekanat-philnat@unibas.ch |
| Offered by | Departement Biozentrum |