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| Semester | fall semester 2024 |
| Course frequency | Every fall sem. |
| Lecturers |
Urs Duthaler (urs.duthaler@unibas.ch)
Götz Schlotterbeck (g.schlotterbeck@unibas.ch) Iris Schulz (iris.schulz@unibas.ch, Assessor) |
| Content | Course contents Forensic Toxicology: Theme 1 Analytical methods in Forensic Toxicology (2h) • Analytical tools: LC-MS/MS, GC-MS/MS, Immunoassays… • Advantages and limitations Theme 2 Driving under the influence of alcohol and drugs (4h) • Biological matrices, sample preparation and measurement • Blood alcohol, limits, regulations • Relevant drugs, limit substances Theme 3 Hair analysis (2h) • Dealing with hair samples in the forensic context • Application of hair testing in abstinence control and crime case works Theme 4 New psychoactive substances (NPS) and knockout substances (2h) • Analytical tools to assess various compound classes • Case studies Forensic Genetics: Theme 1 Biological basis and current applied DNA analysis (4h) • Tasks of forensic genetics: trace, relationship and identification analyses • Human genome, structure and polymorphism; autosomal and gonosomal DNA short tandem repeats • DNA analysis methods: Immunological pre-tests, microscopy, staining, and differential lysis (DL), extraction, amplification and capillary electrophoresis, profile interpretation (biostatistics, database), law • RNA markers and mtDNA sequencing and their applications Theme 2 Specific DNA and RNA applications (3h) • Single cell isolation: Laser-Capture Microdissection (LCM), DEPArray and microfluidic principles, Flow-Cytometry (DEPArray) • Benefits and limits of classical (DL, LCM) and state-of-the-art technologies • RNA profiling and body fluid identification Theme 3 Future Methods (3h) • Principle of DNA sequencing • Pyrosequencing and Next Generation Sequencing • Phenotyping, biogeographic and age estimation |
| Learning objectives | After completing the module, students will be able to… • possess scientific knowledge of the fundamental principles underlying forensic toxicology and forensic genetics. • know state-of-the-art technologies and future trends in forensic toxicological and forensic genetic methods, including their advances and limitations. • apply acquired knowledge to use existing instrumentations and techniques in forensic practices, and contribute to the development of new methodologies. • can clearly, effectively and concisely present their results to peers as well as to the public in written and oral form according to scientific standards. |
| Admission requirements | The course is designed for students holding a Bachelor’s degree of various backgrounds like engineering, natural sciences, computer sciences, medicine or health sciences |
| Language of instruction | English |
| Use of digital media | No specific media used |
| Interval | Weekday | Time | Room |
|---|---|---|---|
| wöchentlich | Wednesday | 08.15-10.00 | Biozentrum, Seminarraum U1.193 |
| Date | Time | Room |
|---|---|---|
| Wednesday 18.09.2024 | 08.15-10.00 | Biozentrum, Seminarraum U1.193 |
| Wednesday 25.09.2024 | 08.15-10.00 | Biozentrum, Seminarraum U1.193 |
| Wednesday 02.10.2024 | 08.15-10.00 | Biozentrum, Seminarraum U1.193 |
| Wednesday 09.10.2024 | 08.15-10.00 | Biozentrum, Seminarraum U1.193 |
| Wednesday 16.10.2024 | 08.15-10.00 | Biozentrum, Seminarraum U1.193 |
| Wednesday 23.10.2024 | 08.15-10.00 | Biozentrum, Seminarraum U1.193 |
| Wednesday 30.10.2024 | 08.15-10.00 | Biozentrum, Seminarraum U1.193 |
| Wednesday 06.11.2024 | 08.15-10.00 | Biozentrum, Seminarraum U1.193 |
| Wednesday 13.11.2024 | 08.15-10.00 | Biozentrum, Seminarraum U1.193 |
| Wednesday 20.11.2024 | 08.15-10.00 | Biozentrum, Seminarraum U1.193 |
| Wednesday 27.11.2024 | 08.15-10.00 | Biozentrum, Seminarraum U1.193 |
| Wednesday 04.12.2024 | 08.15-10.00 | Biozentrum, Seminarraum U1.193 |
| Wednesday 11.12.2024 | 08.15-10.00 | Biozentrum, Seminarraum U1.193 |
| Wednesday 18.12.2024 | 08.15-10.00 | Biozentrum, Seminarraum U1.193 |
| Modules |
Modul: Image Acquisition and Analysis (Master's Studies: Biomedical Engineering) Module Specialisation: Medical Nanosciences (Master's Studies: Nanosciences) |
| Assessment format | record of achievement |
| Assessment details | • Presentation on selected topics of 10 minutes on last lecture blocks, groups of 2 (50%) • Written outline of presentation, including literature study (50%) |
| Assessment registration/deregistration | Reg.: course registration, dereg: cancel course registration |
| Repeat examination | one repetition, best attempt counts |
| Scale | 1-6 0,1 |
| Repeated registration | as often as necessary |
| Responsible faculty | Faculty of Medicine |
| Offered by | Departement Biomedical Engineering (DBE) |