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| Semester | spring semester 2013 |
| Course frequency | Every spring sem. |
| Lecturers | Christian M.H.R. de Geyter (c.degeyter@unibas.ch, Assessor) |
| Content | Week 1: Embryogenesis and sexual differentation I & II Week 2: Gonadal function: testes, ovaries, hormonal circuits; Toxic effects on gonads: protective measures (blood testis barrier, biotransformation, DNArepair) examples of toxicity Week 3: Testing male reproductive function: animals and humans; Testing female reproductive function: animals and humans Week 4: Placenta: transport of drugs, biotransformation, models; Prenatal toxicity and teratogenicity: mechanisms and examples I Week 5: Prenatal toxicity and teratogenicity: mechanisms and examples II; Peri- and postnatal toxicities, lactation Week 6: Regulatory requirements; In vitro systems and animal models Week 7: Exam |
| Learning objectives | to understand the basic endocrine pathways in the regulation of reproduction in the female and in the male to understand the endocrine pathways in pregnancy to be able to outline embryogenesis and sexual differentiation to understand potential toxic effects of a number of compounds in reproductive toxicology and its mechanisms of action in the gonads, in the embryo & the placenta and during lactation to be able to describe the evaluation systems in use in reproductive toxicology |
| Bibliography | Toxicology, The Basic Science of Poisons, Eds. Casarett & Doull's |
| Weblink | www.ivf-basel.ch |
| Language of instruction | English |
| Use of digital media | No specific media used |
| Interval | Weekday | Time | Room |
|---|
No dates available. Please contact the lecturer.
| Modules |
Module Specialisation: Toxicology (Master Pharmaceutical Sciences) Module Specific Knowledge in Toxicology (Master Toxicology) (Pflicht) |
| Assessment format | continuous assessment |
| Assessment details | Tuseday, 28.05.2013, 08.15 - 10.00, Room BZ106 |
| Assessment registration/deregistration | Reg.: course registration; dereg.: teaching staff |
| Repeat examination | no repeat examination |
| Scale | 1-6 0,5 |
| Repeated registration | as often as necessary |
| Responsible faculty | Faculty of Science, studiendekanat-philnat@unibas.ch |
| Offered by | Departement Pharmazeutische Wissenschaften |