Back
| Semester | spring semester 2008 |
| Course frequency | Irregular |
| Lecturers |
Markus Meuwly (m.meuwly@unibas.ch)
Torsten Schwede (torsten.schwede@unibas.ch, Assessor) |
| Content | Three-dimensional protein structures are key to a detailed understanding of the molecular basis of protein function, to develop rational strategies for experiments such as site directed mutagenesis, studies of disease related mutations, or the development of specific inhibitors. The course will cover modeling and simulation methods applied to protein structures and their interactions with other molecules: protein structure comparison and classification, protein modeling techniques, molecular mechanics simulations, in silico and structure based drug design. |
| Learning objectives | Overview of current methods in computational methods in structural biology, e.g. protein and nucleic acid structure modeling, analysis of structure-function relationships, evolution of protein structures, molecular dynamics simulations and key methods in drug discovery. |
| Bibliography | "Computational Structural Biology: Methods and Applications" (2008) World Scientific Publishing. |
| Comments | Die Veranstaltung besteht aus einer Reihe einführender Vorlesungen (wöchentlich), sowie einem zweitägigen Symposium "Computational Structural Biology" am 13. und 14. März (jeweils ganztägig). |
| Admission requirements | Grundkenntnisse in Strukturbiologie (Strukturen und physikalisch-chemische Eigenschaften der Aminosäuren, Peptide und Proteine, Bauprinzipien von Proteinstrukturen) und Grundlagen in der Bioinformatik (Sequenzvergleiche und Alignements, Evolution) sind notwendig. Programmierkenntnisse sind nicht erforderlich. |
| Language of instruction | English |
| Use of digital media | No specific media used |
| Interval | Weekday | Time | Room |
|---|
No dates available. Please contact the lecturer.
| Modules |
Cycle F: Genomics and Bioinformatics (Master Molecular Biology) Cycle F: Genomics and Bioinformatics (PhD subject: Structural Biology) Cycle F: Genomics and Bioinformatics (PhD subject: Microbiology) Cycle F: Genomics and Bioinformatics (PhD subject: Bioinformatics) Cycle F: Genomics and Bioinformatics (PhD subject: Neurobiology) Cycle F: Genomics and Bioinformatics (PhD subject: Biochemistry) Cycle F: Genomics and Bioinformatics (PhD subject: Cell Biology) Cycle F: Genomics and Bioinformatics (PhD subject: Biophysics) Cycle F: Genomics and Bioinformatics (PhD subject: Genetics) Cycle F: Genomics and Bioinformatics (PhD subject: Pharmacology) |
| Assessment format | continuous assessment |
| Assessment details | Die Leistungsüberprüfung erfolgt in Form eines Seminarvortrags. Themen und Termine werden zu Beginn der Veranstaltung bekanntgegeben. |
| Assessment registration/deregistration | Reg.: course registration; dereg.: teaching staff |
| Repeat examination | no repeat examination |
| Scale | Pass / Fail |
| Repeated registration | as often as necessary |
| Responsible faculty | Faculty of Science, studiendekanat-philnat@unibas.ch |
| Offered by | Departement Biozentrum |