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| Semester | fall semester 2019 |
| Course frequency | Every fall sem. |
| Lecturers |
Hubert Hug (hubert.hug@dsm.com)
Alex Odermatt (alex.odermatt@unibas.ch, Assessor) Maria Tsachaki (maria.tsachaki@unibas.ch) |
| Content | General aspects of carcinogenesis (A. Odermatt) Mechanisms of mutagenesis and carcinogenesis (M. Tsachaki) The role of oncogenes in cancer (M. Tsachaki) Tumor suppressors (M. Tsachaki) Macroscopic genetic alterations and cancer predisposition (M. Tsachaki) Toxicogenomics (H. Hug) Animal models to detect carcinogens (Ph. Bentley) Transgenic animal models used in carcinogenicity (H.-J. Martus) Genotoxicity and carcinogenicity (P. Sagelsdorff) Anticarcinogenesis (H. Nägeli) Targeted anticancer drugs (P. Manley) Tumor models in cancer therapy (M.R. Jensen) Estrogen- and androgen-dependent tumors (A. Odermatt) Treatment of estrogen- and androgen-dependent cancer (A. Odermatt) E-learning forum |
| Learning objectives | To understand the basics of chemical induction of tumorigenesis. To know cancerogenic chemicals and their mechanisms of action. To understand defense mechanisms and the relevance of transport, phase I and phase II detoxification enzymes. To be able to name three oncogenes and tumor suppressor genes and explain their function in the cell. To know tests used in the detection of cancer cells and genetic predisposition. To know animal models used to detect cancerogenic chemicals and to know defense and repair mechanisms. To know chemotherapeutic drugs as well as the mechanisms involved in resistance to such drugs. |
| Bibliography | Arzneimittelwirkungen kompakt. Basiswissen Pharmakologie und Toxikologie, Mutschler Allgemeine und spezielle Pharmakologie und Toxikologie, Aktories The Biology of Cancer, Robert A. Weinberg, Garland Science 2007 |
| Comments | active participation to the e-learning forum is required. Film and sound recordings during the course are strictly forbidden (recorders may be confiscated) |
| Weblink | ADAM |
| Language of instruction | English |
| Use of digital media | No specific media used |
| Interval | Weekday | Time | Room |
|---|
No dates available. Please contact the lecturer.
| Modules |
Electives Master Science in Pharmacy: Recommendations (Master's Studies: Science in Pharmacy) Module: Introduction and Basis of Human Diseases (Master's Studies: Drug Sciences) |
| Assessment format | continuous assessment |
| Assessment details | Electronic written exam (Multiple Choice) https://pharma.unibas.ch/de/teaching/pruefungen-exams/performance-assessments/course-accompanying-examinations/ |
| Assessment registration/deregistration | Reg.: course registration, dereg: cancel course registration |
| Repeat examination | no repeat examination |
| Scale | 1-6 0,5 |
| Repeated registration | as often as necessary |
| Responsible faculty | Faculty of Science, studiendekanat-philnat@unibas.ch |
| Offered by | Departement Pharmazeutische Wissenschaften |