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| Semester | spring semester 2020 |
| Course frequency | Every 2nd spring sem |
| Lecturers | Patrick D. Matthias (patrick.matthias@unibas.ch, Assessor) |
| Content | This course deals with transcriptional regulation and gene expression, in particular in eukaryotes. The emphasis will be put on understanding the regulatory interplay between transcription factors and their crucial role in translating environmental and developmental cues into coordinated activation of the genome. Topics that will be discussed include: Regulatory DNA sequences: promoters, enhancers, locus control regions; General transcription machinery; Transcription factors, cell-specific and ubiquitous; Mechanistic aspects of transcription activation; Chromatin, histone modifications, DNA methylation; Genome 3D organization and its impact on gene expression; Gene regulatory networks; Enhancers and Super-enhancers as integrators of gene activity; Transcription factors as master controlers of cellular differentiation; Transcription factors in health and disease; Functional dissection of transcription control by genome-wide screens; Quantitative analysis of transcription control. |
| Comments | Please contact Patrick Matthias exclusively: patrick.matthias@fmi.ch other lecturers: Jörg Betschinger, Luca Giorgetti and Jeff Chao |
| Weblink | Graduate Teaching Program |
| Language of instruction | English |
| Use of digital media | Online, optional |
| Interval | Weekday | Time | Room |
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No dates available. Please contact the lecturer.
| Modules |
Cycle G: Molecular Biology (Master's Studies: Molecular Biology) Doctorate Biochemistry: Recommendations (PhD subject: Biochemistry) Doctorate Biophysics: Recommendations (PhD subject: Biophysics) Doctorate Cell Biology: Recommendations (PhD subject: Cell Biology) Doctorate Computational Biology: Recommendations (PhD subject: Computational Biology) Doctorate Genetics: Recommendations (PhD subject: Genetics) Doctorate Microbiology: Recommendations (PhD subject: Microbiology) Doctorate Molecular Biology: Recommendations (PhD subject: Molecular Biology) Doctorate Neurobiology: Recommendations (PhD subject: Neurobiology) Doctorate Pharmacology: Recommendations (PhD subject: Pharmacology) Doctorate Structural Biology: Recommendations (PhD subject: Structural Biology) Module Specialisation: Molecular Biology (Master's Studies: Nanosciences) Vertiefungsfächer Theorie und Vertiefungsfächer Biologie (Master's Studies: Computational Biology and Bioinformatics) |
| Assessment format | continuous assessment |
| Assessment registration/deregistration | Reg.: course registration, dereg: cancel course registration |
| Repeat examination | no repeat examination |
| Scale | Pass / Fail |
| Repeated registration | as often as necessary |
| Responsible faculty | Faculty of Science, studiendekanat-philnat@unibas.ch |
| Offered by | Departement Biozentrum |