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| Semester | spring semester 2021 |
| Course frequency | Every spring sem. |
| Lecturers |
Andreas J. Bircher (andreas.bircher@unibas.ch)
Tobias Manigold (tobias.manigold@unibas.ch) Thomas Singer (thomas.singer@unibas.ch) Daniel Yerly (daniel.yerly@unibas.ch) |
| Content | Principles of the immune system; Immunotoxicology of drugs; Immunosafety of biopharmaceuticals (T. Singer) Immunosafety risk assessment; Immunosafety toolbox; Risk mitigation strategy (T. Singer) Principles of T cell stimulation by hapten, prohapten, pi-concept and HLA restricted relations (D. Yerly) Immune reactions to biologicals: principles and clinic; Drugs and antibody productions: IgE mediated reactons (the penicilin model); anaphylaxis, cross-reactivity, pholcodin model (T. Manigold) Immun reactions to biologicals: infusion reactions and cytokine release syndromes: risk assessment. Type II and III reactions (haemolytic anaemia, agranulo-cytosis, throbocytopenia, ...) (T. Manigold) Drugs and the skin: toxicity & contact dermatitis (T. Singer) Drugs and the skin: cutaneous reactions (MPE, SJS/TEN, AGEP) (A. Bircher) Risk assessment in drug hypersensitivity - in vivo or in vitro? Is it possible? Examples (M. Kammüller) Diagnosis of drug hypersensitivity: skin tests, provocation tests, in vitro tests for drug hypersensitivity (A. Bircher) Examination (T. Singer) |
| Learning objectives | The basic principles of immunology should be known by the participants. Know the principles of immunotoxicological hazard identification and risk assessment of drugs. Know the basics of drug-induced hypersensitivity. Understand IgE mediated reactions against drugs. understand the basics of infusion reactions and cytokine release syndromes. Know the basics of skin reactions against drugs. |
| Bibliography | Peter J. Delves, Seamus J. Martin, Dennis R. Burton, Ivan M. Roitt: Roitt's Essential Immunology; 13th Edition; Wiley-Blackwell; 2017 |
| Comments | Film and sound recordings during the course are strictly forbidden (recorders may be confiscated) |
| Weblink | ADAM |
| Admission requirements | Completed Bachelor degree |
| Language of instruction | English |
| Use of digital media | No specific media used |
| Interval | Weekday | Time | Room |
|---|---|---|---|
| wöchentlich | Tuesday | 13.15-15.00 | - Online Präsenz - |
| Date | Time | Room |
|---|---|---|
| Tuesday 02.03.2021 | 13.15-15.00 | - Online Präsenz -, -- |
| Tuesday 09.03.2021 | 13.15-15.00 | - Online Präsenz -, -- |
| Tuesday 16.03.2021 | 13.15-15.00 | - Online Präsenz -, -- |
| Tuesday 23.03.2021 | 13.15-15.00 | - Online Präsenz -, -- |
| Tuesday 30.03.2021 | 13.15-15.00 | - Online Präsenz -, -- |
| Tuesday 06.04.2021 | 13.15-15.00 | - Online Präsenz -, -- |
| Tuesday 13.04.2021 | 13.15-15.00 | - Online Präsenz -, -- |
| Modules |
Electives Master Science in Pharmacy: Recommendations (Master's Studies: Science in Pharmacy) Module: Translating Pharmacology and Drug Safety to Humans (Master's Studies: Drug Sciences) |
| Assessment format | continuous assessment |
| Assessment details | Please refer to the list: https://pharma.unibas.ch/en/translate-to-english-pages/education/assessments-and-credit-points/continuous-assessments/ |
| Assessment registration/deregistration | Reg.: course registration, dereg: cancel course registration |
| Repeat examination | no repeat examination |
| Scale | 1-6 0,5 |
| Repeated registration | as often as necessary |
| Responsible faculty | Faculty of Science, studiendekanat-philnat@unibas.ch |
| Offered by | Departement Pharmazeutische Wissenschaften |