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| Semester | fall semester 2021 |
| Course frequency | Irregular |
| Lecturers |
Isabel Kolinko (isabel.kolinko@unibas.ch)
Michael Nash (michael.nash@unibas.ch, Assessor) |
| Content | Introduction to biomacromolecules; Measurement techniques for characterisation of biomacromolecules; Fundamentals of molecular recognition; Recombinant DNA; Protein engineering; Directed evolution; Protein folding; Polymers; Elastin-like polypeptides; Intelligent materials; Spatially localized hydrogels; Mechanical properties of proteins and macromolecules; Single-molecule force spectroscopy. |
| Learning objectives | The objective is to familiarise the students with a broad range of topics related to biotechnology, nanotechnology, and biophysics with a focus on current research and reading of scientific literature. |
| Bibliography | (1) Alberts, Molecular Biology (Ch.2 Cellular chemistry). (2) Ratner, Biomaterials Science (Ch. 2.3, 2.4 Polymers & hydrogels). (3) Walsh, Protein Biochemistry, (Ch. 2, Protein Structure). (4) Nath et. al. Analytical chemistry, 74(3): 504-509, 2002. (5) DeMonte, D., et. al. Proteins DOI: 10.1002/prot.24320, 2013. (6) Feldhaus, M.J., et al. Nature Biotechnology 21 (2): 163–70, 2003. (7) Link, A.J., et al. PNAS 103 (27): 10180–85, 2006. (8) Chen, I. et al. PNAS 108 (28): 11399–404, 2011. (9) Marín-Navarro, J., et. al. PloS One 10 (12). journals.plos.org: e0144289, 2015. (10) Christensen, T. et al. Biomacromolecules 14 (5): 1514–19, 2013. (11) Shimoboji, T., et al. PNAS. 99(26): 16592-16596, 2002. (12) Puchner, E.M. et al. PNAS. 105(36): 13385–13390, 2008. (13) Dietz, H., et al. PNAS 103 (5): 1244–47, 2006. |
| Comments | Access to Rosental only via gate BPR 1047, Mattenstrasse 24a. Students of the University of Basel register on MOnA for an access to the Rosental please until September 14th, 2021. ETH-students need to apply for a badge in advance with an email to: student-admin@bsse.ethz.ch prior the start of the lecture. |
| Course application | Register on MOnA. |
| Language of instruction | English |
| Use of digital media | No specific media used |
| Interval | Weekday | Time | Room |
|---|---|---|---|
| wöchentlich | Wednesday | 08.00-10.00 | Campus Rosental 1095, Seminarraum O02.017 |
| wöchentlich | Thursday | 08.00-09.00 | Campus Rosental 1060, Sitzungsraum 2.14 |
| Modules |
Doctorate Chemistry: Recommendations (PhD subject: Chemistry) Module Specialisation: Chemistry (Master's Studies: Nanosciences) Module Specialisation: Molecular Biology (Master's Studies: Nanosciences) Module: Physical Chemistry (Master's Studies: Chemistry) |
| Assessment format | continuous assessment |
| Assessment details | Weekly discussion of reading assignments; in-class presentation; oral exam |
| Assessment registration/deregistration | Reg.: course registration, dereg: cancel course registration |
| Repeat examination | no repeat examination |
| Scale | 1-6 0,5 |
| Repeated registration | as often as necessary |
| Responsible faculty | Faculty of Science, studiendekanat-philnat@unibas.ch |
| Offered by | Departement Chemie |