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| Semester | fall semester 2022 |
| Course frequency | Every 2nd fall sem. |
| Lecturers |
Birthe Fahrenkrog (birthe.fahrenkrog@unibas.ch)
Roderick Lim (roderick.lim@unibas.ch, Assessor) |
| Content | This course will describe the structure and function of the eukaryotic nucleus. The nucleus serves as the "brain" of the cell. It contains the genetic information and ensures that it is properly replicated, segregated, transcribed and repaired. Within the nucleus are functional compartments such as the nucleolus, whose function it is to produce ribosomes. The nucleus, which is membrane bound, has nuclear pores, which are complex, regulated machines that control the flow of material into and out of a nucleus. In this course, all features of the nucleus from regulated import/export through pores, to the compartmentalization of transcription, splicing, replication and repair will be covered. We will cover the pathology of nuclear defects, with a focus on mutations in structural components of the nucleus and how they compromise the integrity of the genome to cause tissue-specific disease. The structure and function of lamins and pore proteins in transcriptional control will be presented, as well as the structure and folding of chromosomes and their dynamics through the cell cycle. Subdiffusive movements of chromatin in interphase nuclei and the role of this dynamic behavior in repair and transcription will be discussed. The lectures will give an up-to-date overview of a complex structure-function problem that touches on crucial aspects of cell identity. |
| Weblink | Graduate Teaching Program |
| Language of instruction | English |
| Use of digital media | Online, optional |
| Interval | Weekday | Time | Room |
|---|---|---|---|
| wöchentlich | Friday | 09.15-11.15 | Biozentrum, Seminarraum U1.193 |
| Date | Time | Room |
|---|---|---|
| Friday 23.09.2022 | 09.15-11.15 | Biozentrum, Seminarraum U1.193 |
| Friday 30.09.2022 | 09.15-11.15 | Biozentrum, Seminarraum U1.193 |
| Friday 07.10.2022 | 09.15-11.15 | Biozentrum, Seminarraum U1.193 |
| Friday 14.10.2022 | 09.15-11.15 | Biozentrum, Seminarraum U1.193 |
| Friday 21.10.2022 | 09.15-11.15 | Biozentrum, Seminarraum U1.193 |
| Friday 28.10.2022 | 09.15-11.15 | Biozentrum, Seminarraum U1.193 |
| Friday 04.11.2022 | 09.15-11.15 | Biozentrum, Seminarraum U1.193 |
| Friday 11.11.2022 | 09.15-11.15 | Biozentrum, Seminarraum U1.193 |
| Friday 18.11.2022 | 09.15-11.15 | Biozentrum, Seminarraum U1.193 |
| Friday 25.11.2022 | 09.15-11.15 | Dies Academicus |
| Friday 02.12.2022 | 09.15-11.15 | Biozentrum, Seminarraum U1.193 |
| Friday 09.12.2022 | 09.15-11.15 | Biozentrum, Seminarraum U1.193 |
| Friday 16.12.2022 | 09.15-11.15 | Biozentrum, Seminarraum U1.193 |
| Modules |
Cycle C: Growth & Development (Master's Studies: Molecular Biology) Doctorate Biochemistry: Recommendations (PhD subject: Biochemistry) Doctorate Biophysics: Recommendations (PhD subject: Biophysics) Doctorate Cell Biology: Recommendations (PhD subject: Cell Biology) Doctorate Computational Biology: Recommendations (PhD subject: Computational Biology) Doctorate Genetics: Recommendations (PhD subject: Genetics) Doctorate Microbiology: Recommendations (PhD subject: Microbiology) Doctorate Molecular Biology: Recommendations (PhD subject: Molecular Biology) Doctorate Neurobiology: Recommendations (PhD subject: Neurobiology) Doctorate Pharmacology: Recommendations (PhD subject: Pharmacology) Doctorate Structural Biology: Recommendations (PhD subject: Structural Biology) Module Specialisation: Molecular Biology (Master's Studies: Nanosciences) |
| Assessment format | continuous assessment |
| Assessment registration/deregistration | Reg.: course registration, dereg: cancel course registration |
| Repeat examination | no repeat examination |
| Scale | Pass / Fail |
| Repeated registration | as often as necessary |
| Responsible faculty | Faculty of Science, studiendekanat-philnat@unibas.ch |
| Offered by | Departement Biozentrum |