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10415-01 - Main lecture: Structural Biology (2 CP)
| Semester | spring semester 2024 |
| Course frequency | Every spring sem. |
| Lecturers | Timm Maier (timm.maier@unibas.ch, Assessor) |
| Content | Programm: 1. Introduction: anatomy of a protein, structure determination methods, molecular graphics 2. From polypeptide to structure: interactions, folds, homology 3. Structure/function relationships: proteases, kinase, phosphotases 4. Conformational changes: allosteric control, molecular symmetry, signal transduction 5. Filaments and aggregates: cytoskeleton, prions, amyloids 6. Molecular motors 7. Membranes and membrane proteins: transporters and channels, receptors 8. DNA structure and replication, RNA biosynthesis and nucleocytoplasmic transport 9. The ribosome, protein biosynthesis, chaperones, quality control & degradation 10. Bioenergetics: Mitochondrian ATP synthesis and Photosynthesis 11. Biosynthetic networks and complexes, multienzymes and assembly lines 12. Metabolic regulation: Sensors, signalling modules and cascades and the TOR complexes 13. Questions & Answers, test exam in subgroups |
| Learning objectives | Folgende Fragen sollten am Ende des Kurses u.a. beantwortet werden können: Welche molekularen Wechselwirkungen bewirken Strukturbildung, welche wiederkehrenden Strukturmuster gibt es, inwieweit ist strukturelle Flexibilität wichtig, wie werden biologische Strukturen bestimmt, wozu werden strukturelle Erkenntnisse eingesetzt, wie können Strukturen vorhergesagt werden? Des weiteren werden die Studierenden mit ausgewählten Beispielen zu Struktur-Funktionsbeziehungen vertraut gemacht. |
| Bibliography | Vortragsmaterialien werden elektronisch zur Verfügung gestellt. Generelle Biochemie- und Zellbiologie-Lehrbücher können zur Vor- und Nachbearbeitung herangezogen werden: - Textbook Of Structural Biology, Anders Liljas, Lars Liljas, Jure Piskur, Göran Lindblom, Poul Nissen, Morten Kjeldgaard (ISBN 978-9812772084) - Lehninger Principles of Biochemistry, 7th Edition, David L. Nelson, Michael M. Cox (ISBN 978-1319108243) - Fundamentals of Biochemistry: Life at the Molecular Level, 5th Edition, Donald Voet, Judith G. Voet, Charlotte W. Pratt (ISBN 978-1-118-91846-3) Detaillierte Angaben, auch zu Originalliteratur, erfolgen in den Vorlesungen. Elektronische Feedback-Möglichkeit via Mobilgerät auf www.movo.ch |
| Weblink | https://adam.unibas.ch |
| Language of instruction | English |
| Use of digital media | No specific media used |
| Course auditors welcome |
| Interval | Weekday | Time | Room |
|---|---|---|---|
| wöchentlich | Tuesday | 10.15-12.00 | Biozentrum, Hörsaal U1.131 |
| einmalig | See individual dates | ||
Dates
| Date | Time | Room |
|---|---|---|
| Tuesday 27.02.2024 | 10.15-12.00 | Biozentrum, Hörsaal U1.131 |
| Tuesday 05.03.2024 | 10.15-12.00 | Biozentrum, Hörsaal U1.131 |
| Tuesday 05.03.2024 | 12.15-13.45 | Biozentrum, Seminarraum U1.193 |
| Tuesday 12.03.2024 | 10.15-12.00 | Biozentrum, Hörsaal U1.131 |
| Tuesday 12.03.2024 | 12.15-13.45 | Biozentrum, Seminarraum U1.193 |
| Tuesday 19.03.2024 | 10.15-12.00 | Biozentrum, Hörsaal U1.131 |
| Tuesday 26.03.2024 | 10.15-12.00 | Biozentrum, Hörsaal U1.131 |
| Tuesday 02.04.2024 | 10.15-12.00 | Biozentrum, Hörsaal U1.131 |
| Thursday 04.04.2024 | 13.00-15.00 | Biozentrum, Seminarraum 02.054 |
| Tuesday 09.04.2024 | 10.15-12.00 | Biozentrum, Hörsaal U1.131 |
| Tuesday 16.04.2024 | 10.15-12.00 | Biozentrum, Hörsaal U1.131 |
| Tuesday 23.04.2024 | 10.15-12.00 | Biozentrum, Hörsaal U1.131 |
| Tuesday 30.04.2024 | 10.15-12.00 | Biozentrum, Hörsaal U1.131 |
| Tuesday 07.05.2024 | 10.15-12.00 | Biozentrum, Hörsaal U1.131 |
| Tuesday 14.05.2024 | 10.15-12.00 | Biozentrum, Hörsaal U1.131 |
| Tuesday 21.05.2024 | 10.15-12.00 | Biozentrum, Hörsaal U1.131 |
| Tuesday 28.05.2024 | 10.15-12.00 | Biozentrum, Hörsaal U1.131 |
| Modules |
Modul: Computational Biology (Bachelor's Studies: Computational Sciences) Modul: Computational Biology (Bachelor's Studies: Computational Sciences) Modul: Computational Biology (Bachelor's Studies: Computational Sciences) Modul: Computational Biology (Bachelor's Studies: Computational Sciences) Modul: Computational Biology (Bachelor's Studies: Computational Sciences) Modul: Naturwissenschaften (Bachelor's Studies: Computational Sciences) Modul: Naturwissenschaften (Bachelor's Studies: Computational Sciences) Modul: Naturwissenschaften (Bachelor's Studies: Computational Sciences) Modul: Naturwissenschaften (Bachelor's Studies: Computational Sciences) Module: Biology 4 (Bachelor's degree subject: Biology) Module: Biology 4 (Bachelor's Studies: Biology (Start of studies before 01.08.2022)) Module: Biology 4 (Bachelor's Studies: Biology) Module: Computational Biology (Bachelor's Studies: Computational Sciences (Start of studies before 01.08.2023)) Module: Molecular Biology (Bachelor's Studies: Nanosciences) Module: Natural Sciences (Bachelor's Studies: Computational Sciences (Start of studies before 01.08.2023)) |
| Assessment format | exam |
| Assessment details | Written exam after the 4th semester, 45 Min. All informations about the exam, like registration, duration, date and type of the exam, will be announced on https://philnat.unibas.ch/de/examen (For provisional dates see https://bio.unibas.ch/en/examinations/main-lecture-exams/) |
| Assessment registration/deregistration | Reg.: in 'course reg.'; dereg.: Dean of Std. Off. in writing |
| Repeat examination | one repetition, best attempt counts |
| Scale | 1-6 0,5 |
| Repeated registration | no repetition |
| Responsible faculty | Faculty of Science, studiendekanat-philnat@unibas.ch |
| Offered by | Departement Biozentrum |